Hiv-1 Reverse Transcriptase

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 THR-216   PRO-217  24.0 22.9 54.7 -24.6 15.1 27.8 56.4
 PRO-217   ASP-218  23.2 20.7 -16.9 4.1 103.3 92.2 4.3
 ASP-218   LYS-219  21.8 20.8 -172.7 27.9 104.2 99.0 -82.4
 LYS-219   LYS-220  18.9 18.1 -114.1 49.0 33.6 141.3 -18.3
 LYS-220   HIS-221  17.0 17.1 72.5 31.2 85.5 94.8 -99.7
 HIS-221   GLN-222  13.8 16.8 40.0 -86.0 67.8 150.9 33.2
 GLN-222   LYS-223  15.6 15.0 173.1 59.8 76.5 82.3 89.0
 LYS-223   GLU-224  12.6 11.7 -145.8 -72.9 66.6 66.3 189.9
 GLU-224   PRO-225  8.9 8.7 22.8 9.3 157.7 113.1 -64.4

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 VAL-314   HIS-315  9.5 11.1 -31.4 70.8 92.5 110.4 46.3
 HIS-315   GLY-316  6.1 7.6 -12.6 76.7 139.9 169.8 117.5
 GLY-316   VAL-317  5.0 6.5 -30.6 -4.3 95.7 92.7 -9.4

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees