Monoclonal Antibody 2D12.5, Igg1 Gamma Heavy Chain

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLU-6   SER-7  10.8 11.0 -1.6 2.4 98.6 97.5 -6.2
 SER-7   GLY-8  9.6 9.8 17.3 24.1 39.6 37.3 256.1
 GLY-8   PRO-9  8.6 9.0 -143.4 4.5 84.7 95.9 -168.5
 PRO-9   GLY-10  7.6 6.3 15.4 0.2 104.7 132.8 -93.5
 GLY-10   LEU-11  4.1 5.1 110.2 -21.0 88.2 72.5 126.5
 LEU-11   VAL-12  6.5 6.7 8.0 -1.2 156.9 152.5 -42.0
 VAL-12   GLN-13  6.7 7.1 9.2 -14.7 82.5 80.7 18.1
 GLN-13   PRO-14  10.2 10.5 -1.4 1.2 67.8 57.9 -1.4
 PRO-14   SER-15  11.4 11.4 11.1 4.5 172.5 166.0 -118.6
 SER-15   GLN-16  11.0 11.2 -9.9 -0.8 58.0 63.3 59.9

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 THR-114   VAL-115  2.3 2.3 -2.3 -6.4 54.5 54.6 36.9
 VAL-115   THR-116  0.9 1.0 -8.4 15.4 117.8 116.2 22.7
 THR-116   VAL-117  4.5 4.5 -3.8 -1.4 45.4 44.4 25.4

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees