Inositol-Trisphosphate 3-Kinase A

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  LYS-277   ALA-278  14.6 15.4 -98.5 117.5 81.3 103.6 -35.2  LYS-283   LEU-284  9.1 8.7 -78.8 63.0 73.9 65.1 80.6 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  ARG-314   TYR-315  5.8 5.9 1.2 11.7 62.0 63.8 64.4  GLN-317   TRP-318  6.0 6.1 -6.6 5.5 110.8 109.5 -23.1  TRP-318   ARG-319  2.6 2.6 1.8 -4.9 55.3 51.2 -13.1 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees