DNA Topoisomerase II, Alpha Isozyme

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 PRO-263   VAL-264  9.5 9.7 -23.9 9.0 20.2 14.1 161.1
 VAL-264   LYS-265  8.6 8.7 -18.3 30.3 54.7 52.2 -100.2
 LYS-265   GLY-266  10.1 10.2 8.4 -19.4 157.1 158.2 119.7

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Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees