Proto-Oncogene Tyrosine-Protein Kinase

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LYS-276   GLN-277  18.4 18.1 4.6 -16.6 141.0 145.5 70.2
 GLN-277   GLY-278  19.3 18.5 -23.0 43.6 97.8 77.7 -4.1
 ALA-284   PHE-285  17.1 16.9 -13.3 -18.7 119.7 140.2 -96.6
 PHE-285   LEU-286  14.2 14.2 16.1 7.2 99.7 92.5 16.9
 LEU-286   ALA-287  11.6 11.6 3.9 -8.9 73.2 63.3 11.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ALA-305   VAL-306  0.5 1.1 5.8 4.2 79.9 83.0 20.9
 VAL-306   VAL-307  3.7 4.1 22.1 2.2 34.2 36.1 108.7
 VAL-307   THR-308  6.0 6.0 19.4 -12.3 74.4 67.3 8.3
 THR-308   GLN-309  7.9 7.5 5.0 -9.6 58.4 60.8 -12.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 TYR-318   MET-319  4.1 4.5 -8.3 26.2 160.1 158.9 93.3
 MET-319   GLU-320  3.4 3.8 7.5 -3.1 55.8 61.8 -28.5
 GLU-320   ASN-321  6.5 7.0 8.2 4.2 40.8 37.8 42.7

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees