Beta-Secretase 1

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ILE-202   ILE-203  8.1 8.1 -0.4 6.6 105.7 107.5 70.9
 ILE-203   VAL-204  6.5 6.6 0.1 3.0 25.0 27.3 23.1
 VAL-204   ARG-205  4.2 4.3 -6.0 9.3 131.8 134.2 18.9

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ASP-223   LYS-224  17.8 18.1 1.4 13.2 33.6 36.3 473.0
 LYS-224   SER-225  15.6 16.2 -20.5 -4.7 102.2 91.9 -212.6
 SER-225   ILE-226  13.1 13.2 -9.4 1.6 170.0 171.0 -136.6

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 VAL-227   ASP-228  12.3 12.2 0.6 -3.1 130.8 133.5 110.5
 ASP-228   SER-229  15.6 15.4 2.9 -0.4 121.1 118.9 -110.8
 SER-229   GLY-230  16.2 16.0 -7.7 19.4 85.2 82.8 -34.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 THR-275   PRO-276  31.4 31.3 -7.8 -5.2 58.0 57.4 203.4
 PRO-276   TRP-277  29.9 29.8 9.5 -8.6 85.6 89.6 -26.8
 TRP-277   ASN-278  26.4 26.2 -0.9 -12.2 45.5 42.8 123.5
 ASN-278   ILE-279  25.8 25.6 4.4 20.0 144.8 155.1 -324.4

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LEU-285   TYR-286  7.5 7.5 2.7 6.3 77.1 77.1 69.2
 TYR-286   LEU-287  3.7 3.8 0.0 7.4 69.3 68.1 55.3
 LEU-287   MET-288  2.7 2.8 3.4 -0.9 95.2 96.7 -51.0

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 SER-295   PHE-296  2.9 2.7 -4.4 10.4 63.2 60.8 -16.4
 PHE-296   ARG-297  3.3 3.4 0.9 0.4 78.9 76.8 40.3
 ARG-297   ILE-298  5.3 5.4 -4.1 6.4 39.6 40.6 -9.7

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 PRO-308   VAL-309  28.6 28.4 -3.6 12.1 107.8 107.9 125.0
 VAL-309   GLU-310  31.4 30.8 3.8 -11.6 51.5 41.5 -151.5
 GLU-310   ASP-311  33.2 32.1 1.5 33.3 94.8 88.3 86.9
 ASP-311   VAL-312  37.0 35.9 45.8 -49.4 126.9 143.7 6.1

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 VAL-332   MET-333  15.8 15.9 -3.4 -3.9 106.7 103.5 -59.8
 MET-333   GLY-334  13.7 13.7 1.2 8.0 29.6 29.3 128.6
 GLY-334   ALA-335  16.5 16.3 11.2 0.7 59.5 63.0 -59.3
 ALA-335   VAL-336  17.1 17.0 6.2 -3.0 119.3 126.0 10.4
 VAL-336   ILE-337  17.8 17.3 -9.7 9.4 82.9 90.6 21.9
 ILE-337   MET-338  14.1 13.5 -3.2 -3.5 151.4 157.3 -81.8
 MET-338   GLU-339  12.8 12.7 5.3 -3.6 56.7 60.9 116.1

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ARG-366   THR-367  20.9 20.8 12.1 -23.4 147.9 148.5 144.9
 THR-367   ALA-368  18.1 17.9 20.8 0.4 79.3 77.5 153.6
 ALA-368   ALA-369  14.8 14.5 -10.8 4.4 80.8 85.2 15.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 VAL-370   GLU-371  8.2 8.4 6.7 -4.9 103.9 108.0 87.3
 GLU-371   GLY-372  8.4 8.6 -4.2 6.9 63.3 66.3 1.0
 GLY-372   PRO-373  7.5 7.6 -6.2 -0.5 96.4 91.0 3.2

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LEU-377   ASP-378  6.7 6.2 6.7 -2.5 89.7 87.2 57.2
 ASP-378   MET-379  8.5 7.9 3.7 -7.0 125.9 129.7 152.1
 MET-379   GLU-380  7.0 6.8 -0.4 -1.3 74.1 73.6 -14.6

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees