Epidermal Growth Factor Receptor

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ILE-744   LYS-745  10.0 9.8 -3.7 9.8 119.8 116.0 12.6
 LYS-745   GLU-746  9.1 8.5 -2.9 5.4 148.1 144.5 14.8
 GLU-746   LEU-747  8.5 7.5 -29.7 15.7 100.7 107.7 4.1
 LEU-747   ARG-748  9.4 6.8 108.0 -170.9 25.3 14.2 -98.9
 ARG-748   GLU-749  11.0 8.7 -28.5 -1.2 122.7 113.9 -27.9
 GLU-749   ALA-750  9.9 6.8 -171.7 -34.6 117.9 95.5 136.3

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ALA-767   SER-768  2.4 1.9 -4.5 9.3 141.9 165.3 7.0
 SER-768   VAL-769  5.2 3.9 -9.1 35.8 150.0 124.0 47.3
 VAL-769   ASP-770  4.1 3.6 -38.1 11.6 121.3 117.8 5.3
 ASP-770   ASN-771  1.8 1.4 -4.9 18.1 149.8 145.4 12.5
 ASN-771   PRO-772  3.7 4.3 -4.9 2.2 82.3 86.2 2.9

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees