Metabotropic Glutamate Receptor Subtype 1

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  SER-207   ASP-208  1.5 1.9 -12.9 9.2 106.2 105.7 -4.5  ASP-208   THR-209  2.4 2.0 1.5 -15.5 97.7 100.8 -13.0  THR-209   LEU-210  4.6 4.3 13.9 1.4 27.2 29.7 44.0 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  LYS-341   LEU-342  5.7 5.5 26.7 -20.5 96.3 89.6 -16.3  LEU-342   GLN-343  3.1 3.2 1.5 9.0 154.4 156.4 -5.9  GLN-343   SER-344  2.6 2.8 84.0 -57.1 101.3 86.4 -0.8  SER-344   PRO-345  6.3 6.5 -36.4 -10.3 20.3 27.2 134.9  PRO-345   GLU-346  7.4 7.4 -8.5 -9.8 84.8 83.4 5.7  GLU-346   VAL-347  10.0 10.6 3.1 -20.2 97.4 95.9 3.2 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  PRO-476   GLY-477  8.1 8.0 40.2 18.7 68.1 69.9 56.3  GLY-477   ARG-478  4.4 4.6 0.8 15.6 60.2 21.9 39.8  ARG-478   TYR-479  2.7 3.3 -30.9 15.1 112.5 96.8 4.9  TYR-479   ASP-480  1.6 2.0 1.7 0.0 49.0 29.6 -2.2  ASP-480   ILE-481  4.1 3.8 -17.3 -13.4 72.3 70.3 19.4  ILE-481   MET-482  7.9 7.6 -6.0 1.1 130.0 131.0 -7.7 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees