Mitogen-Activated Protein Kinase 8

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 CYS-79   VAL-80  5.1 5.3 -42.2 47.0 89.6 74.7 -54.8
 VAL-80   ASN-81  1.4 1.6 -5.3 -20.1 27.9 29.6 158.7
 ASN-81   HIS-82  2.8 2.6 23.3 -18.2 86.5 92.5 14.6

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 ILE-85   ILE-86  5.1 5.1 4.6 12.0 40.4 44.9 88.6
 ILE-86   GLY-87  4.7 4.4 -14.3 7.7 77.5 81.7 24.1
 GLY-87   LEU-88  2.7 1.4 -30.8 23.9 116.9 109.3 -13.2

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLU-109   LEU-110  3.8 3.7 8.1 -32.2 101.2 109.4 118.5
 LEU-110   MET-111  6.6 6.3 -2.7 -2.9 95.4 80.5 35.6
 MET-111   ASP-112  8.8 8.3 -4.5 12.1 47.7 47.2 -5.8

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LEU-168   ASP-169  9.9 9.6 -27.3 -5.6 44.9 51.0 176.1
 ASP-169   PHE-170  11.2 9.9 -5.2 35.6 25.7 21.1 -177.5
 PHE-170   GLY-171  10.3 9.1 6.8 -25.7 135.3 122.0 125.5
 GLY-171   LEU-172  13.7 12.8 29.2 -33.9 122.6 127.5 68.5

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 PRO-333   PRO-334  8.2 9.0 2.8 15.9 92.1 85.1 -2.6
 PRO-334   PRO-335  4.7 5.3 22.7 -19.9 65.9 59.8 9.2
 PRO-335   LYS-336  2.6 4.0 165.7 -75.0 140.3 120.0 -428.9

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees