Isocitrate Dehydrogenase

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i		 Residue
i+1		 Distance of hinge axis to residue i in conformer 1
(A) 		Distance of hinge axis to residue i in conformer 2
(A) 		Change in psi (i)
(deg) 		Change in phi (i+1)
(deg) 		Angle of psi(i) axis to hinge axis conformer 1
(deg) 		Angle of psi(i) axis to hinge axis conformer 2
(deg) 		Percentage Progress
 TYR-125   ILE-126  2.4 2.3 1.4 2.9 142.3 141.5 -11.1
 ILE-126   CYS-127  2.1 2.0 -4.9 -1.4 29.4 37.8 43.2
 CYS-127   LEU-128  2.6 2.6 -6.8 6.2 54.5 52.5 3.8
 LEU-128   ARG-129  2.4 2.3 -0.3 0.0 16.4 17.2 -11.8

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees

Residue
i		 Residue
i+1		 Distance of hinge axis to residue i in conformer 1
(A) 		Distance of hinge axis to residue i in conformer 2
(A) 		Change in psi (i)
(deg) 		Change in phi (i+1)
(deg) 		Angle of psi(i) axis to hinge axis conformer 1
(deg) 		Angle of psi(i) axis to hinge axis conformer 2
(deg) 		Percentage Progress
 VAL-131   ARG-132  5.6 5.3 4.9 11.2 50.3 55.3 94.1
 ARG-132   TYR-133  7.0 6.8 4.4 3.6 25.8 26.2 10.7
 TYR-133   TYR-134  6.7 6.4 -11.4 18.3 116.5 113.6 0.2
 TYR-134   GLN-135  5.5 4.8 5.1 -10.2 14.1 17.8 -1.4
 GLN-135   GLY-136  6.9 6.4 4.0 -19.3 55.6 48.7 -48.2
 GLY-136   THR-137  4.0 4.1 28.9 -20.9 109.9 109.1 -11.4
 THR-137   PRO-138  2.5 2.3 16.0 -1.5 72.1 74.7 26.2

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees

Residue
i		 Residue
i+1		 Distance of hinge axis to residue i in conformer 1
(A) 		Distance of hinge axis to residue i in conformer 2
(A) 		Change in psi (i)
(deg) 		Change in phi (i+1)
(deg) 		Angle of psi(i) axis to hinge axis conformer 1
(deg) 		Angle of psi(i) axis to hinge axis conformer 2
(deg) 		Percentage Progress
 ILE-322   ALA-323  3.7 3.6 -16.3 -3.6 39.1 37.5 88.7
 ALA-323   PRO-324  2.6 2.4 3.3 -1.4 136.5 140.1 -3.7
 PRO-324   GLY-325  2.3 2.3 -1.2 5.0 28.8 26.3 -10.6

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees