Syk Kinase

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  PRO-167   TRP-168  1.6 1.8 11.3 -19.2 60.0 57.0 -29.2  TRP-168   PHE-169  4.9 4.9 13.5 -9.2 53.8 56.9 43.6  PHE-169   HIS-170  5.0 4.9 10.2 -6.1 41.4 39.2 149.0 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees