Fibroblast Growth Factor Receptor 2

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 VAL-639   MET-640  19.3 18.9 0.2 -7.0 82.5 82.0 -0.7
 MET-640   LYS-641  15.8 15.5 5.7 -9.4 128.1 125.0 2.8
 LYS-641   ILE-642  13.1 12.6 -7.1 1.7 103.6 103.5 -4.4
 ILE-642   ALA-643  9.5 8.9 1.9 7.7 147.9 151.4 -10.3
 ALA-643   ASP-644  7.2 6.7 -19.8 1.3 98.3 98.2 -5.2
 ASP-644   PHE-645  4.1 3.1 -28.4 -10.8 104.1 121.2 -19.6

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LEU-665   PRO-666  8.6 11.7 -57.7 13.9 54.5 84.9 33.5
 PRO-666   VAL-667  6.6 8.1 -78.6 -22.6 15.9 41.5 109.0
 VAL-667   LYS-668  7.5 8.5 17.9 -5.4 134.7 140.8 -3.8
 LYS-668   TRP-669  6.6 7.4 6.6 1.4 85.7 80.4 -0.5
 TRP-669   MET-670  3.2 4.1 -6.6 8.6 86.8 89.6 2.7
 MET-670   ALA-671  3.4 3.9 2.1 -0.4 151.8 153.6 -0.8
 ALA-671   PRO-672  4.3 4.1 0.1 -7.4 104.5 106.5 3.6

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees