Proto-Oncogene Tyrosine-Protein Kinase Src

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LYS-316   LEU-317  4.4 4.4 -15.1 44.6 144.2 147.3 124.5
 LEU-317   ARG-318  5.1 5.5 0.6 0.3 61.8 60.0 27.1
 ARG-318   HIS-319  5.8 6.2 -8.7 2.8 131.2 139.3 -17.7

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LEU-325   TYR-326  3.4 3.1 -26.6 31.5 112.2 129.9 15.7
 TYR-326   ALA-327  6.9 5.6 -10.5 12.4 151.2 150.3 1.7
 ALA-327   VAL-328  8.2 7.6 -6.8 -1.5 88.8 84.9 33.7

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 MET-341   SER-342  5.4 6.4 6.2 -18.5 36.6 35.4 -33.2
 SER-342   LYS-343  7.6 8.8 9.7 30.5 42.3 32.0 145.1
 LYS-343   GLY-344  5.6 6.3 -24.6 17.1 78.5 85.5 25.0

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 VAL-402   ALA-403  5.3 5.4 -4.2 1.7 125.0 128.6 -5.1
 ALA-403   ASP-404  5.2 5.3 -6.1 -10.2 112.5 111.1 -41.8
 ASP-404   PHE-405  8.3 8.4 -17.2 41.0 131.4 113.9 39.7
 PHE-405   GLY-406  8.4 9.4 116.0 -14.5 49.9 72.7 218.5
 GLY-406   LEU-407  11.3 13.1 89.0 43.8 67.8 7.5 -824.7
 LEU-407   ALA-408  13.6 12.4 -22.8 -31.1 109.3 108.6 1005.6
 ALA-408   ARG-409  11.7 15.9 -127.9 55.3 170.4 72.8 -196.9
 PHE-424   PRO-425  22.5 22.4 -3.4 -60.9 62.6 43.8 134.7
 PRO-425   ILE-426  20.6 20.2 3.2 1.5 83.8 88.2 -23.0
 ILE-426   LYS-427  23.7 23.2 4.6 -4.4 136.1 134.3 -23.0

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees