Asp/glu-Specific Dipeptidyl-Peptidase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Asp/glu-Specific Dipeptidyl-Peptidase
  Conformer 1
(PDB)
5jxk (B)
  Conformer 2
(PDB)
5jwi (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 481 1.0   24 - 294   341 - 384   542 - 714
2 196 0.95   295 - 340   385 - 541

Sequence


           ________________________________________________________________________________________________________________________ 
 5jxk(B) : *DGGMWLMQQINGQVARMKSLGMQLEAADIYNPNGSSLKDAVVMFDGGCTGVLVSNQGLLLTNHHCGYDQIQKHSSVQHNYLKDGFWSYSLAEELVNPGLEVEIVDEITDVTAAVKKELE 
         :                                                                                                                          
 5jwi(A) : MDGGMWLMQQINGQVARMKSLGMQLEAADIYNPNGSSLKDAVVMFDGGCTGVLVSNQGLLLTNHHCGYDQIQKHSSVQHNYLKDGFWSYSLAEELVNPGLEVEIVDEITDVTAAVKKELE 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 5jxk(B) : R---pSGLEFLSPRYLSSLAPEIV----aSRPGYRYEIKAFYGGNRYYMFTKKVFRDVRLVAAPPSSIGKFGSDTDNWAWPRHTGDFSIFRLYADKNGNPAEYSKDNVPYRPKRWVKVNA 
         :                                                                                                                          
 5jwi(A) : RIKKPSGLEFLSPRYLSSLAPEIVGKKAASRPGYRYEIKAFYGGNRYYMFTKKVFRDVRLVAAPPSSIGKFGSDTDNWAWPRHTGDFSIFRLYADKNGNPAEYSKDNVPYRPKRWVKVNA 
           ________________________________________________________________________________________________________________________ 

           _______________________________294___________________________________________340________________________________________ 
 5jxk(B) : QGVKEGDFALIMGYPGTTYKFFTADEVTEWSEIDNNIRIEMRGILQDVMLREMLADPKINIMYAAKYASSQNGYKRAQGANWAIRRRSLREIKLAQQQEVLAWAKQKGIATTEEAVRAIS 
         :                                                                                                                          
 5jwi(A) : QGVKEGDFALIMGYPGTTYKFFTADEVTEWSEIDNNIRIEMRGILQDVMLREMLADPKINIMYAAKYASSQNGYKRAQGANWAIRRRSLREIKLAQQQEVLAWAKQKGIATTEEAVRAIS 
           _______________________________294___________________________________________340________________________________________ 

           _384____________________________________________________________________________________________________________________ 
 5jxk(B) : KAIEGRQDLRMRQRYLLEGILMGIEMSNAPAADSDIA-------rREAGLQSIRKQFEAFFNKDYSPEVEKDQLAIALLTRYAERIPAEKQPISIREGIAEYGSAKAYVEMIFDKSIYAS 
         :                                                                                                                          
 5jwi(A) : KAIEGRQDLRMRQRYLLEGILMGIEMSNAPAADSDIADHWDDPARREAGLQSIRKQFEAFFNKDYSPEVEKDQLAIALLTRYAERIPAEKQPISIREGIAEYGSAKAYVEMIFDKSIYAS 
           _384____________________________________________________________________________________________________________________ 

           ______________________________________541_______________________________________________________________________________ 
 5jxk(B) : RERFEEFMKNPDRDRLLRDPMSRFAASVAYEHQKLAKEVAAFDAPLAAAQRSYVASVLDMKGQPNLAPDANLTLRFTYGEIKGYQPRDVVTYGAKSTLEGVMEKEDPNNWEYVVDPKLKA 
         :                                                                                                                          
 5jwi(A) : RERFEEFMKNPDRDRLLRDPMSRFAASVAYEHQKLAKEVAAFDAPLAAAQRSYVASVLDMKGQPNLAPDANLTLRFTYGEIKGYQPRDVVTYGAKSTLEGVMEKEDPNNWEYVVDPKLKA 
           ______________________________________541_______________________________________________________________________________ 

           _________________________________________________________________________________________________                        
 5jxk(B) : LYEAKNYGRYANSDGSMPVNFCATTHTTGGNAGSPVMNARGELIGLNFDRNWEGVGGDIEYLPNYQRSIILDIRYLLFIIDKFAGCQRLIDEIQPQ*                        
         :                                                                                                                          
 5jwi(A) : LYEAKNYGRYANSDGSMPVNFCATTHTTGGNAGSPVMNARGELIGLNFDRNWEGVGGDIEYLPNYQRSIILDIRYLLFIIDKFAGCQRLIDEIQPQF                        
           _________________________________________________________________________________________________                        

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
18.0
Translation
(A)
-0.5
Closure
(%)
84.1
Bending Residues
( green )
  294 - 295
  340 - 346
  384 - 385
  541 - 543
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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