Coagulation Factor VIII

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Coagulation Factor VIII
  Conformer 1
(PDB)
2r7e (A)
  Conformer 2
(PDB)
6mf2 (A)
  Window Length 11
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 587 2.55   6 - 689   694 - 695
2 27 8.55   690 - 693   696 - 719

Sequence


           ________________________________________________________________________________________________________________________ 
 2r7e(A) : ATRRYYLGAVELSWDYMQSDLGELPVDARFPPRVPKSFPFNTSVVYKKTLFVEFTDHLFNIAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEYDDQTSQ 
         :                                                                                                                          
 6mf2(A) : ATRRYYLGAVELSWDYMQS-----------------------sVVYKKTLFVEFTDHLFNIAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEYDDQTSQ 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 2r7e(A) : REKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSGLIGALLVCREGSLAKEKTQTLHKFILLFAVFDEGKSWHSETKNaASARAWPKMHTVNGYVNRSLPGLIG 
         :                                                                                                                          
 6mf2(A) : REKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSGLIGALLVCREGSLAKEKTQTLHKFILLFAVFDEGKSWHS----------wPKMHTVNGYVNRSLPGLIG 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 2r7e(A) : CHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQfDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEED 
         :                                                                                                                          
 6mf2(A) : CHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPE--------------------kHPKTWVHYIAAEEED 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 2r7e(A) : WDYAPLVLAPDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKTREAIQHESGILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKDFPILPGEIFKYK 
         :                                                                                                                          
 6mf2(A) : WDYAPLVLAPDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKTREAIQHESGILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKDFPILPGEIFKYK 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 2r7e(A) : WTVTVEDGPTKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGNQIMSDKRNVILFSVFDENRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSLQLSVCLH 
         :                                                                                                                          
 6mf2(A) : WTVTVEDGPTKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYK--------------rNVILFSVFDENRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSLQLSVCLH 
           ________________________________________________________________________________________________________________________ 

           __________________________661_____________________________693___________________________________________________________ 
 2r7e(A) : EVAYWYILSIGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRNRGMTALLKVSSCDKNTGDYYEDSYED*************************** 
         :                                                                                                                          
 6mf2(A) : EVAYWYILSIGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRNRGMTALLKVSSC-kKTRHYFIAAVERLWDYGMSvPQFKKVVFQEFTDGSFTQP 
           __________________________661_____________________________693___________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 2r7e(A) : ************************************************************************************************************************ 
         :                                                                                                                          
 6mf2(A) : LYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLISYEEDpRKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVD-----LEKD-VH-----SGL-IGPLLVCHT 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 2r7e(A) : ************************************************************************************************************************ 
         :                                                                                                                          
 6mf2(A) : NTLNPAHGRQVTVQEFALFFTIFDETKSWYFTENMEReDPTFKENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNEN----------IHSIHFSGHVFTVRKKEEYKMALYNLYP 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 2r7e(A) : ************************************************************************************************************************ 
         :                                                                                                                          
 6mf2(A) : GVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYSNKCQTPLGMASGHIRDFQITASGQYGQWAPKLARLHYSGSINAWSTKEPFSWIKVDLLAPMIIHGIKTQGARQKFSSLYISQ 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 2r7e(A) : ************************************************************************************************************************ 
         :                                                                                                                          
 6mf2(A) : FIIMYSLDGKKWQTYRGNSTGTLMVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNSCSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWR 
           ________________________________________________________________________________________________________________________ 

           ___________________________________________________________________________________________________________________      
 2r7e(A) : *******************************************************************************************************************      
         :                                                                                                                          
 6mf2(A) : PQVNNPKEWLQVDFQKTMKVTGVTTQGV---KSLLTSMYVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCEAQDLY      
           ___________________________________________________________________________________________________________________      

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
102.0
Translation
(A)
0.5
Closure
(%)
25.0
Bending Residues
( green )
  661 - 690
  693 - 697
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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