DynDom - Protein Domain Motions

DNA Mismatch Repair Protein Muts

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	DNA Mismatch Repair Protein Muts
Conformer 1 (PDB)	1e3m (A)
Conformer 2 (PDB)	1w7a (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	653	2.05	116 - 798
2	76	1.18	16 - 115

Sequence

`____________________________________________________________________________________________________________115_________` `1e3m(A) : SAIENFDAHTPqQYLRLKAQHPEILLFYR-gDFYELFYDDAKRASQLLDISLTKRGASAGEPIPaGIPYHAVENYLAKLVNQGESVAICEQIGDPATSKGPVERKVVRIVTPGTISDEAL` `:` `1w7a(B) : **********MQQYLRLKAQHPEILLFYRMGDFYELFYDDAKRASQLLDISLT--------pM-AGIPYHAVENYLAKLVNQGESVAICE-------------rKVVRIVTPGTISDEAL` `____________________________________________________________________________________________________________115_________` `________________________________________________________________________________________________________________________` `1e3m(A) : LQERQDNLLAAIWQDSKGFGYATLDISSGRFRLSEPADRET-aAELQRTNPAELLYAEDFAE-sLIEGRRGLRRRPLWEFEIDTARQQLNLQFGTRDLVGFGVENAPRGLCAAGCLLQYA` `:` `1w7a(B) : LQERQDNLLAAIWQDSKGFGYATLDISSGRFRLSEPADRETMAAELQRTNPAELLYAEDFAEMSLIEGRRGLRRRPLWEFEIDTARQQLNLQFGTRDLVGFGVENAPRGLCAAGCLLQYA` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1e3m(A) : KDTQRTTLPHIRSIT-eREQDSII-dAATRRNLEITQNLAGGAENTLASVLDCTVTP-gSR-lKRWLH-pVRDTRVLLERQQTIGALQDFTAGLQPVLRQVGDLERILARLALRTARPRD` `:` `1w7a(B) : KDTQRTTLPHIRSITMEREQDSIIMDAATRRNLEITQNLAGGAENTLASVLDCTVTPMGSRMLKRWLHMPVRDTRVLLERQQTIGALQDFTAGLQPVLRQVGDLERILARLALRTARPRD` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1e3m(A) : LAR-rHAFQQLPELRAQLETVDSAPVQALREK-gEFAELRDLLERAIIDTPPVLVRDGGVIASGYNEELDEWRALADGATDYLERLEVRERERTGLDTLKVGFNAVHGYYIQISRGQSHL` `:` `1w7a(B) : LARMRHAFQQLPELRAQLETVDSAPVQALREKMGEFAELRDLLERAIIDTPPVLVRDGGVIASGYNEELDEWRALADGATDYLERLEVRERERTGLDTLKVGFNAVHGYYIQISRGQSHL` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1e3m(A) : APINY-rRQTLKNAERYIIPELKEYEDKVLTSKGKALALEKQLYEELFDLLLPHLEALQQSASALAELDVLVNLAERAYTLNYTCPTFIDKPGIRITEGRHPVVEQVLNEPFIANPLNLS` `:` `1w7a(B) : APINYMRRQTLKNAERYIIPELKEYEDKVLTSKGKALALEKQLYEELFDLLLPHLEALQQSASALAELDVLVNLAERAYTLNYTCPTFIDKPGIRITEGRHPVVEQVLNEPFIANPLNLS` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1e3m(A) : PQRR-lIITGPN-gGKSTY-rQTALIAL-aYIGSYVPAQKVEIGPIDRIFTRVG----------fvE-tETANILHNATEYSLVL-dEIGRGTSTYDGLSLAWACAENLANKIKALTLFA` `:` `1w7a(B) : PQRRMLIITGPNMGGKSTYMRQTALIALMAYIGSYVPAQKVEIGPIDRIFTRVGAADDsGRSTFMVEMTETANILHNATEYSLVLMDEIGRGTSTYDGLSLAWACAENLANKIKALTLFA` `________________________________________________________________________________________________________________________` `__________________________________________________________________________` `1e3m(A) : THYFELTQLPEK-eGVANVHLDALEHGDTIAF-hSVQDGAASKSYGLAVAALAGVPKEVIKRARQKLRELESIS` `:` `1w7a(B) : THYFELTQLPEKMEGVANVHLDALEHGDTIAFMHSVQDGAASKSYGLAVAALAGVPKEVIKRARQKLRELESIS` `__________________________________________________________________________`

Morph

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Status: Initialising

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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	28.1
Translation (A)	-1.3
Closure (%)	81.5
Bending Residues ( green )	115 - 116
Bending Region Analysis

Dynamic Contact Graph

The dynamic contact graph is still being generated. Progress: Initialising

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