DynDom - Protein Domain Motions

2-Methylcitrate Synthase, Mitochondrial

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	2-Methylcitrate Synthase, Mitochondrial
Conformer 1 (PDB)	5uqo (A)
Conformer 2 (PDB)	5uqu (A)
Window Length	9
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	310	0.42	35 - 82 95 - 307 361 - 363 365 - 365 369 - 373 414 - 418 426 - 460
2	116	1.05	83 - 94 308 - 360 364 - 364 366 - 368 374 - 413 419 - 425

Sequence

`_____________________________________________________82__________94_____________________________________________________` `5uqo(A) : **AEPDLKTALKAVIPAKRELFKQVKERSDEVIGEVKVANVIGGMRGLKSMLWEGSVLDPEEGIRFHGKTIKDCQKELPKGTSGTEMLPEAMFWLLLTGQVPSTNQVRAFSRELAEQSH` `:` `5uqu(A) : GSTAEPDLKTALKAVIPAKRELFKQVKERSDEVIGEVKVANVIGGMRGLKSMLWEGSVLDPEEGIRFHGKTIKDCQKELPKGTSGTEMLPEAMFWLLLTGQVPSTNQVRAFSRELAEQSH` `_____________________________________________________82__________94_____________________________________________________` `________________________________________________________________________________________________________________________` `5uqo(A) : LPQHILDLIKSFPRSMHPMTQLSIAVAALNTESKFAKAYEKGLSKADYWEPTFDDSISLLAKIPRVAALVFRPDEVDQVGTQALDASQDWSYNFAELLGKGGKENQDFHDLLRLYLALHG` `:` `5uqu(A) : LPQHILDLIKSFPRSMHPMTQLSIAVAALNTESKFAKAYEKGLSKADYWEPTFDDSISLLAKIPRVAALVFRPDEVDQVGTQALDASQDWSYNFAELLGKGGKENQDFHDLLRLYLALHG` `________________________________________________________________________________________________________________________` `________________________________302_______________________________________________________360_____368___________________` `5uqo(A) : DHEGGNVSAHATHLVGSALSDPFLSYSAGLLGLAGPLHGLAAQEVLRWILAMQDKIGTKFTDDDVRNYLWDTLKSGRVVPGYGHGVLRKPDPRFQALMDFAATRPDVLANPVFQLVKKNS` `:` `5uqu(A) : DHEGGNVSAHATHLVGSALSDPFLSYSAGLLGLAGPLHGLAAQEVLRWILAMQDKIGTKFTDDDVRNYLWDTLKSGRVVPGYGHAVLRKPDPRFQALMDFAATRPDVLANPVFQLVKKNS` `________________________________302_______________________________________________________360_____368___________________` `_______________________413__418____425________________________________________` `5uqo(A) : EIAPAVLTEHGKTKNPHPNVDAASGVLFYHYGFQQPLYYTVTFGVSRALGPLVQLIWDRALGLPIERPKSINLLGLK` `:` `5uqu(A) : EIAPAVLTEHGKTKNPHPNVDAASGVLFYHYGFQQPLYYTVTFGVSRALGPLVQLIWDRALGLPIERPKSINLLGLKK` `_______________________413__418____425________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	5.3
Translation (A)	0.4
Closure (%)	49.4
Bending Residues ( green )	82 - 83 94 - 95 302 - 310 360 - 366 368 - 374 413 - 416 418 - 419 425 - 427
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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