5-Methyltetrahydropteroyltriglutamate--Homocysteine Methyltransferase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name 5-Methyltetrahydropteroyltriglutamate--Homocysteine Methyltransferase
  Conformer 1
(PDB)
4qqu (A)
  Conformer 2
(PDB)
4l6h (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 467 1.35   3 - 401   405 - 410   505 - 510   515 - 538   572 - 578   583 - 592   618 - 634
2 290 1.24   402 - 404   411 - 504   511 - 514   539 - 571   579 - 582   593 - 617   635 - 765

Sequence


           ________________________________________________________________________________________________________________________ 
 4qqu(A) : MVQSSVLGFPRIGGQRELKKITEAYWSGKATVEELLAKGKELREHNWKLQQKAGVDIIPSNDFSYYDQVLDLSLLFNAIPERYTKFDLAPIDVLFAMGRGLQAAATtQAAVDVTALEMVK 
         :                                                                                                                          
 4l6h(A) : MVQSSVLGFPRIGGQRELKKITEAYWSGKATVEELLAKGKELREHNWKLQQKAGVDIIPSNDFSYYDQVLDLSLLFNAIPERYTKFDLAPIDVLFAMGRGLQAAAT-qAAVDVTALEMVK 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 4qqu(A) : WFDSNYHYVRPTFSHSTEFKLNTAAGIKPVDEFNEAKALGVQTRPVILGPVSYLYLGKADKDSLDLEPISLLPKILPVYKELLQKLKEAGAEQVQIDEPVLVLDLPEAVQSKFKEAYDAL 
         :                                                                                                                          
 4l6h(A) : WFDSNYHYVRPTFSHSTEFKLNTAAGIKPVDEFNEAKALGVQTRPVILGPVSYLYLGKADKDSLDLEPISLLPKILPVYKELLQKLKEAGAEQVQIDEPVLVLDLPEAVQSKFKEAYDAL 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 4qqu(A) : VGADVPELILTTYFGDVRPNLKAIENLPVAGFHFDFVRVPEQLDEVASILKDGQTLSAGVVDGRNIWKTDFAKASAVVQKAIEKVGKDKVVVATSSSLLHTPVDLESETKLDAVIKDWFS 
         :                                                                                                                          
 4l6h(A) : VGADVPELILTTYFGDVRPNLKAIENLPVAGFHFDFVRVPEQLDEVASILKDGQTLSAGVVDGRNIWKTDFAKASAVVQKAIEKVGKDKVVVATSSSLLHTPVDLESETKLDAVIKDWFS 
           ________________________________________________________________________________________________________________________ 

           _____________________________________401____408_________________________________________________________________________ 
 4qqu(A) : FATQKLDEVVVIAKNVSGEDVSKQLEANAASIKARSESSITNDPKVQERLTTINEALATRKAAFPERLTEQKAKYNLPLFPTTTIGSFPQTKDIRINRNKFAKGQITAEEYEAFINKEIE 
         :                                                                                                                          
 4l6h(A) : FATQKLDEVVVIAKNVSGEDVSKQLEANAASIKARSESSITNDPKVQERLTTINEALATRKAAFPERLTEQKAKYNLPLFPTTTIGSFPQTKDIRINRNKFAKGQITAEEYEAFINKEIE 
           _____________________________________401____408_________________________________________________________________________ 

           ____________________504___510_514_____________________538______________________________571____578___________592_________ 
 4qqu(A) : TVVRFQEEIGLDVLVHGEPERNDMVQYFGEQLNGFAFTTNGWVQSYGSRYVRPPIIVGDVSRPKAMTVKESVYAQSITSKPMKGMLTGPVTILRWSFPRDDVSGKIQALQLGLALRDEVN 
         :                                                                                                                          
 4l6h(A) : TVVRFQEEIGLDVLVHGEPERNDMVQYFGEQLNGFAFTTNGWVQSYGSRYVRPPIIVGDVSRPKAMTVKESVYAQSITSKPMKGMLTGPVTILRWSFPRDDVSGKIQALQLGLALRDEVN 
           ____________________504___510_514_____________________538______________________________571____578___________592_________ 

           _____________617______________634_______________________________________________________________________________________ 
 4qqu(A) : DLEGAGITVIQVDEPAIREGLPLRAGKERSDYLNWAAQSFRVATSGVENSTQIHSHFCYSDLDPNHIKALDADVVSIEFSKKDDPNYIQEFSEYPNHIGLGLFDIHSPRIPSKQEFVSRI 
         :                                                                                                                          
 4l6h(A) : DLEGAGITVIQVDEPAIREGLPLRAGKERSDYLNWAAQSFRVATSGVENSTQIHSHFC---lDPNHIKALDADVVSIEFSK-dDPNYIQEFSEYPNHIGLGLFDIHSPRIPSKQEFVSRI 
           _____________617______________634_______________________________________________________________________________________ 

           ______________________________________________                                                                           
 4qqu(A) : EEILKVYPASKFWVNPDCGLKTRGWPEVKESLTNMVEAAKEFRAKY                                                                           
         :                                                                                                                          
 4l6h(A) : EEILKVYPASKFWVNPDCGLKTRGWPEVKESLTNMVEAAKEFRAKY                                                                           
           ______________________________________________                                                                           

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
For more advanced options, right click on the model.


Show console


play backwards pause play forwards

Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
15.2
Translation
(A)
0.5
Closure
(%)
86.2
Bending Residues
( green )
  401 - 405
  408 - 411
  504 - 507
  510 - 511
  514 - 515
  538 - 539
  571 - 572
  578 - 583
  592 - 593
  617 - 618
  634 - 635
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

Download and extract PyMOL PML script file Download