Bifunctional Glutathionylspermidine Synthetase/amidase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Bifunctional Glutathionylspermidine Synthetase/amidase
  Conformer 1
(PDB)
2iob (B)
  Conformer 2
(PDB)
2io8 (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 354 1.4   28 - 45   52 - 52   77 - 80   202 - 494   507 - 507   509 - 515   571 - 616
2 164 0.66   15 - 27   46 - 51   53 - 76   81 - 201
3 37 0.72   502 - 506   508 - 508   516 - 570

Sequence


           ________________27____________________49_________________________76__80_________________________________________________ 
 2iob(B) : ***GTLLGYAPGGVAIYSSDYSSLDPQEYEDDAVFRSYIDDEYMGHKWQCVEFARRFLFLNYGVVFTDVGMAWEIFSLRFLREVVNDNILPLQAFPNGSPRAPVAGALLIWDKGGEFKDT 
         :                                                                                                                          
 2io8(B) : APFGTLLGYAPGGVAIYSSd------------AVFRSYIDDEYMGHKWQCVEFARRFLFLNYGVVFTDVGMAWEIFSLRFLREVVNDNILPLQAFPNGSPRAPVAGALLIWDKGGEFKDT 
           ________________27____________________49_________________________76__80_________________________________________________ 

           _____________________________________________________________________201________________________________________________ 
 2iob(B) : GHVAIITQLHGNKVRIAEQNVIHSPLPQGQQWTRELEMVVENGCYTLKDTFDDTTILGWMIQTEDTEYSLPQPEIAGELLKISGARLENKGQFDGKWLDEKDPLQNAYVQANGQVINQDP 
         :                                                                                                                          
 2io8(B) : GHVAIITQLHGNKVRIAEQNVIHSPLPQGQQWTRELEMVVENGCYTLKDTFDDTTILGWMIQTEDTEYSLPQPEIAGELLKISGARLENKGQFDGKWLDEKDPLQNAYVQANGQVINQDP 
           _____________________________________________________________________201________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 2iob(B) : YHYYTITESAEQELIKATNELHLMYLHATDKVLKDDNLLALFDIPKILWPRLRLSWQRRRHHMITGRMDFCMDERGLKVYEYNADSASCHTEAGLILERWAEQGYKGNGFNPAEGLINEL 
         :                                                                                                                          
 2io8(B) : YHYYTITESAEQELIKATNELHLMYLHATDKVLKDDNLLALFDIPKILWPRLRLSWQRRRHHMITGRMDFCMDERGLKVYEYNADSASCHTEAGLILERWAEQGYKGNGFNPAEGLINEL 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 2iob(B) : AGAWKHSRARPFVHIMQDKDIEENYHAQFMEQALHQAGFETRILRGLDELGWDAAGQLIDGEGRLVNCVWKTWAWETAFDQIREVSDREFAAVPIRTGHPQNEVRLIDVLLRPEVLVFEP 
         :                                                                                                                          
 2io8(B) : AGAWKHSRARPFVHIMQDKDIEENYHAQFMEQALHQAGFETRILRGLDELGWDAAGQLIDGEGRLVNCVWKTWAWETAFDQIREV----fAAVPIRTGHPQNEVRLIDVLLRPEVLVFEP 
           ________________________________________________________________________________________________________________________ 

           __494_________506______515___________________________________________________569________________________________________ 
 2iob(B) : LWTVIPGNKAILPILWSLFPHHRYLLDTDFTVNDELVKTGYAVKPI-------iDLV-----------------kNIYQQLWCLPKVDGKYIQVCTFTVGGNYGGTCLRGDESLVIKKES 
         :                                                                                                                          
 2io8(B) : LWTVIPGNKAILPILWSLFPHHRYLLDTDFTVNDELVKTGYAVKPIAGRCGSNIDLVSHHEEVLDKTSGKFAEQKNIYQQLWCLPKVDGKYIQVCTFTVGGNYGGTCLRGDESLVIKKES 
           __494_________506______515___________________________________________________569________________________________________ 

           _________                                                                                                                
 2iob(B) : DIEPLIVVK                                                                                                                
         :                                                                                                                          
 2io8(B) : DIEPLIVVK                                                                                                                
           _________                                                                                                                

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
10.2
Translation
(A)
1.2
Closure
(%)
27.4
Bending Residues
( green )
  27 - 46
  49 - 53
  76 - 78
  80 - 81
  201 - 202
Bending Region Analysis
Property Value
Fixed Domain
( blue )
1
Moving Domain
( yellow )
3
Rotation Angle
(deg)
16.7
Translation
(A)
0.2
Closure
(%)
99.1
Bending Residues
( green )
  494 - 502
  506 - 509
  515 - 517
  569 - 571
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Mixed

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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