DynDom - Protein Domain Motions

Calmodulin-Sensitive Adenylate Cyclase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Calmodulin-Sensitive Adenylate Cyclase
Conformer 1 (PDB)	1k8t (A)
Conformer 2 (PDB)	1xfx (D)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	468	9.22	293 - 771
2	24	1.39	772 - 795

Sequence

`________________________________________________________________________________________________________________________` `1k8t(A) : **********************************************************************************************************************` `:` `1xfx(D) : NNLVKTEFTNETLDKIQQTQDLLKKIPKDVLEIYSELGGEIYFTDIDLVEHKELQDLSEEEKNSMNSRGEKVPFASRFVFEKKRETPKLIINIKDYAINSEQSKEVYYEIGKGISLDIIS` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1k8t(A) : ********************************************************************************************************DRIDVLKGEKALK` `:` `1xfx(D) : KDKSLDPEFLNLIKSLSDDSDSSDLLFSQKFKEKLELNNKSIDINFIKENLTEFQHAFSLAFSYYFAPDHRTVLELYAPDMFEYMNKLEKGGFEKISESLKKEGVEKDRIDVLKGEKALK` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1k8t(A) : ASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGK` `:` `1xfx(D) : ASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGK` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1k8t(A) : KEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPD` `:` `1xfx(D) : KEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPD` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1k8t(A) : STKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGT-----------nEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEF` `:` `1xfx(D) : STKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEF` `________________________________________________________________________________________________________________________` `_________________________________________________________________________________________________________771____________` `1k8t(A) : IKNLSSIRRSSNVGVYKDSGDKDEFAKKESVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKSNIEFKLLYKQLNFT` `:` `1xfx(D) : IKNLSSIRRSSNVGVYKDSGDKDEFAKKESVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKSNIEFKLLYKQLNFT` `_________________________________________________________________________________________________________771____________` `________________` `1k8t(A) : ENETDNFEVFQKIIDE` `:` `1xfx(D) : ENETDNFEVFQKIID` `________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
For more advanced options, right click on the model.

play backwards

pause

play forwards

Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	174.2
Translation (A)	-8.0
Closure (%)	46.8
Bending Residues ( green )	771 - 773
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

Download and extract PyMOL PML script file

Download