Cyclin-Dependent Kinase 6

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Cyclin-Dependent Kinase 6
  Conformer 1
(PDB)
1bi7 (A)
  Conformer 2
(PDB)
2f2c (B)
  Window Length 11
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 222 3.16   15 - 161   182 - 296
2 20 6.7   162 - 181

Sequence


           ________________________________________________________________________________________________________________________ 
 1bi7(A) : *DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQ-----------------------eHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 
         :                                                                                                                          
 2f2c(B) : ADQQYEC-aEIG----gKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVS-tDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 
           ________________________________________________________________________________________________________________________ 

           ______________________________161_________________181___________________________________________________________________ 
 1bi7(A) : LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 
         :                                                                                                                          
 2f2c(B) : LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP---- 
           ______________________________161_________________181___________________________________________________________________ 

           _________________________________________________________                                                                
 1bi7(A) : LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ****                                                                
         :                                                                                                                          
 2f2c(B) : ---qAF----aQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER                                                                
           _________________________________________________________                                                                

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
146.1
Translation
(A)
-4.8
Closure
(%)
64.8
Bending Residues
( green )
  161 - 162
  181 - 186
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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