Cgmp-Specific 3',5'-Cyclic Phosphodiesterase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Cgmp-Specific 3',5'-Cyclic Phosphodiesterase
  Conformer 1
(PDB)
1t9r (A)
  Conformer 2
(PDB)
2h40 (A)
  Window Length 15
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 262 2.12   542 - 650   686 - 853
2 21 5.37   651 - 685

Sequence


           __________________________________________________________________________________________________________________650___ 
 1t9r(A) : EEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSH 
         :                                                                                                                          
 2h40(A) : *EETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSH 
           __________________________________________________________________________________________________________________650___ 

           _________________________681____________________________________________________________________________________________ 
 1t9r(A) : DLDH--------------lAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWP 
         :                                                                                                                          
 2h40(A) : DLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWP 
           _________________________681____________________________________________________________________________________________ 

           ___________________________________________________________________________                                              
 1t9r(A) : IQQRIAELVATEFFDQlMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQEK                                              
         :                                                                                                                          
 2h40(A) : IQQRIAELVATEFFDQ-GDReKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQ**                                              
           ___________________________________________________________________________                                              

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
68.9
Translation
(A)
-1.3
Closure
(%)
9.7
Bending Residues
( green )
  650 - 651
  681 - 687
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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