Beta-Secretase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Beta-Secretase
  Conformer 1
(PDB)
1sgz (A)
  Conformer 2
(PDB)
2p4j (A)
  Window Length 15
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 336 0.41   19 - 61   81 - 105   111 - 378
2 24 0.8   62 - 80   106 - 110

Sequence


           _______________________________________________________________61_________________80______________________105__110______ 
 1sgz(A) : GSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWE 
         :                                                                                                                          
 2p4j(A) : GSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWE 
           _______________________________________________________________61_________________80______________________105__110______ 

           ________________________________________________________________________________________________________________________ 
 1sgz(A) : GILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRL 
         :                                                                                                                          
 2p4j(A) : GILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRL 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1sgz(A) : PKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAV 
         :                                                                                                                          
 2p4j(A) : PKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAV 
           ________________________________________________________________________________________________________________________ 

           _____________________________                                                                                            
 1sgz(A) : SACHVHDEFRTAAVEGPFVTLDMEDCGYN                                                                                            
         :                                                                                                                          
 2p4j(A) : SACHVHDEFRTAAVEGPFVTLDMEDCGYN                                                                                            
           _____________________________                                                                                            

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
12.1
Translation
(A)
-0.1
Closure
(%)
71.9
Bending Residues
( green )
  61 - 62
  80 - 81
  105 - 106
  110 - 114
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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