Crispr-Associated Endonuclease Cas9/csn1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Crispr-Associated Endonuclease Cas9/csn1
  Conformer 1
(PDB)
4cmp (A)
  Conformer 2
(PDB)
4oo8 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 372 8.95   57 - 446
2 514 8.67   6 - 55   719 - 1273   1319 - 1353
3 170 3.3   447 - 712

Sequence


           ___________________________________________________55___________________________________________________________________ 
 4cmp(A) : *KYSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEATRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLE------------rHPIFGNI 
         :                                                                                                                          
 4oo8(A) : KKYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEATRLKRTARRRYTRRKNRILYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGNI 
           ___________________________________________________55___________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 4cmp(A) : VDEVAYHEKYPTIYHLRKKLVDSTDKADLRLIYLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPGEKKNGLFGNLI 
         :                                                                                                                          
 4oo8(A) : VDEVAYHEKYPTIYHLRKKLVDSTDKADLRLIYLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPGEKKNGLFGNLI 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 4cmp(A) : ALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAILLSDILRkAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGAS 
         :                                                                                                                          
 4oo8(A) : ALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAILLSDILRkAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGAS 
           ________________________________________________________________________________________________________________________ 

           ___________________________________________________________________________446__________________________________________ 
 4cmp(A) : QEEFYKFIKPILEKMDGTEELLVKLNREDLLRKQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFR----------------------------------------- 
         :                                                                                                                          
 4oo8(A) : QEEFYKFIKPILEKMDGTEELLVKLNREDLLRKQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRFAWMTRKSEETITPWNFEEVVDKGASA 
           ___________________________________________________________________________446__________________________________________ 

           ________________________________________________________________________________________________________________________ 
 4cmp(A) : --------------pNEKVLPKHSLLYEYFTVYNELTKV------------lSGEQKKAIVDLLFKTNRKVTVKQLKED-------------------fNASLGTYHDLLKIIKDKDFLD 
         :                                                                                                                          
 4oo8(A) : QSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAFLSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIEEFDSVEISGVEDRFNASLGTYHDLLKIIKDKDFLD 
           ________________________________________________________________________________________________________________________ 

           _____________________________________________________________________________________________________712________________ 
 4cmp(A) : NEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDk----TILDFLK------rNFMQLIHDDSLTFKEDIQKAQVSdSLHEHIANLAGSP 
         :                                                                                                                          
 4oo8(A) : NEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAQV-dSLHEHIANLAGSP 
           _____________________________________________________________________________________________________712________________ 

           ________________________________________________________________________________________________________________________ 
 4cmp(A) : AIKKGILQTVKVVDELVKVMGRHKPENIVIEMA-----kNSRERMKRIEEGIKELhPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSDYDVDHIVPQSFLKDDSIDNKVLTR--kN 
         :                                                                                                                          
 4oo8(A) : AIKKGILQTVKVVDELVKVMGRHKPENIVIEMARENQTkNSRERMKRIEEGIKELGS-eNTQLQNEKLYLYYLQNGRDMYVDQELDINRLSDYDVDAIVPQSFLKDDSIDNKVLTRSDKN 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 4cmp(A) : RGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRKFDNLTK-----lSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDFRKDFQFYKVREINNYHH 
         :                                                                                                                          
 4oo8(A) : RGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIKRQLVETRQITKHVAQILDSRMNT--------iREVKVITLKSKLVSDFRKDFQFYKVREINNYHH 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 4cmp(A) : AHDAYLNAVVGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQyFFYSNIMNFFKTEITLANGEIRKRPLIETNGETGEIVWDKGRDFATVRKVLSMPQVNIVKKTEVQT--------- 
         :                                                                                                                          
 4oo8(A) : AHDAYLNAVVGTALIKKYPKLESEFVYGDYKVY-iGKATAK---YFFYSNIMNFFKT--------------iETNGETGEIVWDKGRDFATVRKVLSMPQVNIVKKTEVQTGGFSKESIL 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 4cmp(A) : -------------------------pTVAYSVLVV------------sVKELLGITIMERSSFEKNPIDFLEAKG-----kDLIIKLPKYSLFELENGRKRMLASAGELQKGNELALPSK 
         :                                                                                                                          
 4oo8(A) : PKRNSDKLIARKKDWDPKKYGGFDSPTVAYSVLVVAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPKYSLFELENGRKRMLASAGELQKGNELALPSK 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 4cmp(A) : YVNFLYLASHYvEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQSITGLYETRIDLS**** 
         :                                                                                                                          
 4oo8(A) : YVNFLYLASHYpEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQSITGLYE 
           ________________________________________________________________________________________________________________________ 

           _________                                                                                                                
 4cmp(A) : *********                                                                                                                
         :                                                                                                                          
 4oo8(A) : TRIDLSQLG                                                                                                                
           _________                                                                                                                

Morph

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Domain Pairs

Fixed Domain Moving Domain Rotation Angle Translation   (A) Closure Bending Residues  
1 2 119.6 -19.6 98.4   55 - 67 Bending Region Analysis
1 3 178.9 -34.8 92.3   446 - 506 Bending Region Analysis
2 3 152.2 6.4 86.5   712 - 719 Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 2 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 2

Movement classification:

No Contacts

PyMOL Script

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