DynDom - Protein Domain Motions

Citrate Synthase (E.C.4.1.3.7)

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Citrate Synthase (E.C.4.1.3.7)
Conformer 1 (PDB)	5csc (A)
Conformer 2 (PDB)	6csc (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	315	0.8	6 - 56 65 - 274 279 - 281 343 - 345 383 - 431
2	107	2.13	57 - 64 275 - 278 282 - 342 346 - 382

Sequence

`______________________________________________________56______64________________________________________________________` `5csc(A) : ASSTNLKDVLAALIPKEQARIKTFRQQHGGTALGQITVDMSYGGMRGMKGLVYETSVLDPDEGIRFRGFSIPECQKALPKGGgGE-PLPEGLFWLLVTGQIPTGAQVSWLSKEWAKRAAL` `:` `6csc(B) : *TNLKDVLASLIPKEQARIKTFRQQHGNTAVGQITVDMSYGGMRGMKGLIYETSVLDPDEGIRFRGFSIPECQKLLPKAGGGEEPLPEGLFWLLVTGQIPTPEQVSWVSKEWAKRAAL` `______________________________________________________56______64________________________________________________________` `________________________________________________________________________________________________________________________` `5csc(A) : PSHVVTMLDNFPTNLHPMSQLSAAITALNSESNFARAYAEGILRTKYWEMVYESAMDLIAKLPCVAAKIYRNLYRAGSSIGAIDSKLDWSHNFTNMLGYTDAQFTELMRLYLTIHSDHEG` `:` `6csc(B) : PSHVVTMLDNFPTNLHPMSQLSAAITALNSESNFARAYAEGINRTKYWEFVYEDAMDLIAKLPCVAAKIYRNLYRAGSSIGAIDSKLDWSHNFTNMLGYTDPQFTELMRLYLTIHSDHEG` `________________________________________________________________________________________________________________________` `______________________________273_____281__________________________________________________________342__________________` `5csc(A) : GNVSAHTSHLVGSALSDPYLSFAAAMNGLAGPLHGLANQEVLGWLAQLQKAaGADAS---LRDYIWNTLNSGRVVPGYGHAVLRKTDPRYTCQREFALKHLPGDPMFKLVAQLYKIVPNV` `:` `6csc(B) : GNVSAHTSHLVGSALSDPYLSFAAAMNGLAGPLHGLANQEVLLWLSQLQKDLGADASDEKLRDYIWNTLNSGRVVPGYGHAVLRKTDPRYTCQREFALKHLPSDPMFKLVAQLYKIVPNV` `______________________________273_____281__________________________________________________________342__________________` `___________________382_______________________________________________________` `5csc(A) : LLEQGAAANPWPNVDAHSGVLLQYYGMTEMNYYTVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTDGLIAL**` `:` `6csc(B) : LLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYYTVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTAGLEKLSAGG` `___________________382_______________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	16.0
Translation (A)	0.5
Closure (%)	83.4
Bending Residues ( green )	56 - 57 64 - 69 273 - 279 281 - 282 342 - 346 382 - 383
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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