Beta-Secretase 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Beta-Secretase 1
  Conformer 1
(PDB) 		2ohs (A)
  Conformer 2
(PDB) 		2g94 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 345 1.07   1 - 43   51 - 66   78 - 102   110 - 383
2 25 1.07   44 - 50   67 - 77   103 - 109

Sequence


           _____________________________________________43_____50______________66_________77______________________102____109_______ 
 2ohs(A) : **FVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWE 
         :                                                                                                                          
 2g94(A) : GSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWE 
           _____________________________________________43_____50______________66_________77______________________102____109_______ 

           ________________________________________________________________________________________________________________________ 
 2ohs(A) : GILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAg-------------GSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRL 
         :                                                                                                                          
 2g94(A) : GILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRL 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 2ohs(A) : PKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAV 
         :                                                                                                                          
 2g94(A) : PKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAV 
           ________________________________________________________________________________________________________________________ 

           _____________________________                                                                                            
 2ohs(A) : SACHVHDEFRTAAVEGPFVTLDMEDCGYN                                                                                            
         :                                                                                                                          
 2g94(A) : SACHVHDEFRTAAVEGPFVTLDMEDCGYN                                                                                            
           _____________________________                                                                                            

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		16.4
Translation
(A) 		0.4
Closure
(%) 		99.9
Bending Residues
( green ) 		  43 - 44
  50 - 51
  66 - 67
  77 - 78
  102 - 103
  109 - 110
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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