B-Raf Proto-Oncogene Serine/threonine-Protein Kinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name B-Raf Proto-Oncogene Serine/threonine-Protein Kinase
  Conformer 1
(PDB)
3c4d (A)
  Conformer 2
(PDB)
3c4d (B)
  Window Length 7
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 229 1.18   451 - 482   505 - 719
2 22 1.99   483 - 504

Sequence


           ________________________________482___________________504_______________________________________________________________ 
 3c4d(A) : DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYL 
         :                                                                                                                          
 3c4d(B) : DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYL 
           ________________________________482___________________504_______________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 3c4d(A) : HAKSIIHRDLKSNNIFLHEDNTVKIGDFGsGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDER 
         :                                                                                                                          
 3c4d(B) : HAKSIIHRDLKSNNIFLHEDNTVKIGDF-sGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDER 
           ________________________________________________________________________________________________________________________ 

           __________________                                                                                                       
 3c4d(A) : PSFPRILAEIEELARELS                                                                                                       
         :                                                                                                                          
 3c4d(B) : PSFPRILAEIEELARELS                                                                                                       
           __________________                                                                                                       

Morph

Morph animation in progress.
Status: Initialising

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
25.7
Translation
(A)
-1.0
Closure
(%)
65.4
Bending Residues
( green )
  482 - 483
  504 - 506
Bending Region Analysis

Dynamic Contact Graph

The dynamic contact graph is still being generated. Progress: Initialising

PyMOL Script

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