DynDom - Protein Domain Motions

Carminomycin 4-O-Methyltransferase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Carminomycin 4-O-Methyltransferase
Conformer 1 (PDB)	1tw3 (A)
Conformer 2 (PDB)	1tw3 (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	174	0.38	14 - 113 118 - 119 121 - 151 154 - 154 156 - 160 253 - 255 284 - 305 309 - 317 338 - 338
2	162	0.44	114 - 117 120 - 120 152 - 153 155 - 155 161 - 252 256 - 283 306 - 308 318 - 337 339 - 349

Sequence

`___________________________________________________________________________________________________113_117______________` `1tw3(A) : QIDALRTLIRLGSLHTPMVVRTAATLRLVDHILAGARTVKALAARTDTRPEALLRLIRHLVAIGLLEEDAPGEFVPTEVGELLADDHPAAQRAWHDLTQAVARADISFTRLPDAIRTGRP` `:` `1tw3(B) : QIDALRTLIRLGSLHTPMVVRTAATLRLVDHILAGARTVKALAARTDTRPEALLRLIRHLVAIGLLEEDAPGEFVPTEVGELLADDHPAAQRAWHDLTQAVARADISFTRLPDAIRTGRP` `___________________________________________________________________________________________________113_117______________` `______________148_________160_________________________________________________________________________________________25` `1tw3(A) : TYESIYGKPFYEDLAGRPDLRASFDSLLACDQDVAFDAPAAAYDWTNVRHVLDVGGGKGGFAAAIARRAPHVSATVLEMAGTVDTARSYLKDEGLSDRVDVVEGDFFEPLPRKADAIILS` `:` `1tw3(B) : TYESIYGKPFYEDLAGRPDLRASFDSLLACDQDVAFDAPAAAYDWTNVRHVLDVGGGKGGFAAAIARRAPHVSATVLEMAGTVDTARSYLKDEGLSDRVDVVEGDFFEPLPRKADAIILS` `______________148_________160_________________________________________________________________________________________25` `2____________________________283___________________305_________317_______327________________________` `1tw3(A) : FVLLNWPDHDAVRILTRCAEALEPGGRILIHERDDLHENSFNEQFTELDLRMLVFLGGALRTREKWDGLAASAGLVVEEVRQLPSPTIPYDLSLLVLAPA` `:` `1tw3(B) : FVLLNWPDHDAVRILTRCAEALEPGGRILIHERDDLHENSFNEQFTELDLRMLVFLGGALRTREKWDGLAASAGLVVEEVRQLPSPTIPYDLSLLVLAPA` `2____________________________283___________________305_________317_______327________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	4.1
Translation (A)	-0.1
Closure (%)	57.5
Bending Residues ( green )	113 - 114 117 - 121 148 - 156 160 - 161 252 - 253 255 - 256 283 - 284 305 - 306 308 - 309 317 - 318 327 - 339
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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