Crispr-Associated Endonuclease Cas9/csn1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Crispr-Associated Endonuclease Cas9/csn1
  Conformer 1
(PDB)
4cmp (A)
  Conformer 2
(PDB)
4zt0 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 526 5.68   6 - 56   720 - 1281   1341 - 1361
2 368 3.42   57 - 446
3 170 3.52   447 - 718
4 44 5.98   1282 - 1326

Sequence


           ____________________________________________________56__________________________________________________________________ 
 4cmp(A) : *KYSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEATRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLE------------rHPIFGNI 
         :                                                                                                                          
 4zt0(A) : KKYSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEATRLKRTARRRYTRRKNRICYLQEIFSNE-aKVDDSFFHRLEESFLVEEDKKHERHPIFGNI 
           ____________________________________________________56__________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 4cmp(A) : VDEVAYHEKYPTIYHLRKKLVDSTDKADLRLIYLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPGEKKNGLFGNLI 
         :                                                                                                                          
 4zt0(A) : VDEVAYHEKYPTIYHLRKKLVDSTDKADLRLIYLALAH-iKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPGEKKNGLFGNLI 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 4cmp(A) : ALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAILLSDILR------kAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGY 
         :                                                                                                                          
 4zt0(A) : ALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSAS-iKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGY 
           ________________________________________________________________________________________________________________________ 

           _________________________________________________________________________________446____________________________________ 
 4cmp(A) : IDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLRKQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFR----------------------------------- 
         :                                                                                                                          
 4zt0(A) : IDGGASQEEFYKFIKPILEK-dGTEELLVKLNREDLLRKQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRFAWtRKSEETITPWNFEEVVD 
           _________________________________________________________________________________446____________________________________ 

           ________________________________________________________________________________________________________________________ 
 4cmp(A) : ------------------pNEKVLPKHSLLYEYFTVYNELTKV-----------lSGEQKKAIVDLLFKTNRKVTVKQLKED-------------------fNASLGTYHDLLKIIKDKD 
         :                                                                                                                          
 4zt0(A) : KGASAQSFIERtNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGrKPAFLSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGTYHDLLKIIKDKD 
           ________________________________________________________________________________________________________________________ 

           ___________________________________________________________________________________________________________718__________ 
 4cmp(A) : FLDNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDk----TILDFLK------rNFMQLIHDDSLTFKEDIQKAQVS---dSLHEHIA 
         :                                                                                                                          
 4zt0(A) : FLDNEENEDILEDIVLTLTLFEDRE-iEERLKTYAHLFDDKV-kQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNF-qLIHDDSLTFKEDIQKAQVSGQGDSLHEHIA 
           ___________________________________________________________________________________________________________718__________ 

           ________________________________________________________________________________________________________________________ 
 4cmp(A) : NLAGSPAIKKGILQTVKVVDELVKVMGRHKPENIVIEM---------AkNSRERMKRIEEGIKEL-------hPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSDYDVDHIVPQSF 
         :                                                                                                                          
 4zt0(A) : NLAGSPAIKKGILQTVKVVDELVKV-gRHKPENIVIEaRENQTTQKGQKNSRER-kRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRD-yVDQELDINRLSDYDVDHIVPQSF 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 4cmp(A) : LKDDSIDNKVLTR--kNRGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRKFDNLTK-----lSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDF 
         :                                                                                                                          
 4zt0(A) : LKDDSIDNKVLTRSDKNRGKSDNVPSEEVVKK-kNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIKRQLVETRQITKHVAQILDSR-nTKYDENDKLIREVKVITLKSKLVSDF 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 4cmp(A) : RKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQ--------yFFYSNIMNFFKTEITLANGEIRKRPLIETNGETGEIVWDKGRDFATVRKV 
         :                                                                                                                          
 4zt0(A) : RKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDYKVYDVRK-iAKSEQEIGKATAKYFFYSNI-nFFKTEITLANGEIRKRPLIETNGETGEIVWDKGRDFATVRKV 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 4cmp(A) : LSMPQVNIVKKTEVQT----------------------------------pTVAYSVLVV------------sVKELLGITIMERSSFEKNPIDFLEAKG-----kDLIIKLPKYSLFEL 
         :                                                                                                                          
 4zt0(A) : LS-pQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGGFDSPTVAYSVLVVAKVEKGKSKKLKSVKELLGITI-eRSSFEKNPIDFLEAKGYKEVKKDLIIKLPKYSLFEL 
           ________________________________________________________________________________________________________________________ 

           _______________________________________________________1281_________________________________________1326________________ 
 4cmp(A) : ENGRKRMLASAGELQKGNELALPSKYVNFLYLASHYvEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEV 
         :                                                                                                                          
 4zt0(A) : ENGRKRlASAGELQKGNELALPSKYVNFLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDK-PIREQAENIIHLFTLTNLGAPAAFKY 
           _______________________________________________________1266_________________________________________1310________________ 

           ________________________________________                                                                                 
 4cmp(A) : LDA----------------TLIHQSITGLYETRIDLS***                                                                                 
         :                                                                                                                          
 4zt0(A) : FDTTIDRKRYTSTKEVLDATLIHQSITGLYETRIDLSQLG                                                                                 
           ________________________________________                                                                                 

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Domain Pairs

Fixed Domain Moving Domain Rotation Angle Translation   (A) Closure Bending Residues  
1 2 87.1 -5.8 99.6   56 - 68 Bending Region Analysis
1 3 173.2 -2.8 64.1   718 - 720 Bending Region Analysis
1 4 141.0 -6.9 95.3   1281 - 1283   1326 - 1347 Bending Region Analysis
2 3 179.9 -33.7 99.1   446 - 504 Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification:

No Contacts

Conformer 1 Contact:
Residue 1 ———› Residue 4

Conformer 2 Contact:
Residue 4 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 2 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 2

Movement classification: Hinge

PyMOL Script

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