Calpain-1 Catalytic Subunit

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Calpain-1 Catalytic Subunit
  Conformer 1
(PDB)
2g8j (A)
  Conformer 2
(PDB)
1tl9 (A)
  Window Length 9
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 286 1.09   37 - 64   86 - 198   205 - 349
2 27 0.89   65 - 85   199 - 204

Sequence


           ______________________________64___________________85___________________________________________________________________ 
 2g8j(A) : NAIKYLGQDYENLRARCLQNGVLFQDDAFPPVSHSLGFKELGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNETILHRVVPYGQSFQEGYAGIFHFQ 
         :                                                                                                                          
 1tl9(A) : NAIKYLGQDYENLRARCLQNGVLFQDDAFPPVSHSLGFKELGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNETILHRVVPYGQSFQEGYAGIFHFQ 
           ______________________________64___________________85___________________________________________________________________ 

           ___________________________________________198___204____________________________________________________________________ 
 2g8j(A) : LWQFGEWVDVVVDDLLPTKDGKLVFVHSAQGNEFWSALLEKAYAKVNGSYEALSGGCTSEAFEDFTGGVTEWYDLQKAPSDLYQIILKALERGSLLGCSINISDIRDLEAITFKNLVRGH 
         :                                                                                                                          
 1tl9(A) : LWQFGEWVDVVVDDLLPTKDGKLVFVHSAQGNEFWSALLEKAYAKVNGSYEALSGGCTSEAFEDFTGGVTEWYDLQKAPSDLYQIILKALERGSLLGCSINISDIRDLEAITFKNLVRGH 
           ___________________________________________198___204____________________________________________________________________ 

           __________________________________________________________________________________                                       
 2g8j(A) : AYSVTDAKQVTYQGQRVNLIRMRNPWGEVEWKGPWSDNSYEWNKVDPYEREQLRVKMEDGEFWMSFRDFIREFTKLEICNLT                                       
         :                                                                                                                          
 1tl9(A) : AYSVTDAKQVTYQGQRVNLIRMRNPWGEVEWKGPWSDNSYEWNKVDPYEREQLRVKMEDGEFWMSFRDFIREFTKLEICNL*                                       
           __________________________________________________________________________________                                       

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
13.4
Translation
(A)
0.3
Closure
(%)
94.1
Bending Residues
( green )
  64 - 65
  85 - 86
  198 - 199
  204 - 205
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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