Fibroblast Growth Factor Receptor 3

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Fibroblast Growth Factor Receptor 3
  Conformer 1
(PDB) 		4k33 (A)
  Conformer 2
(PDB) 		6pnx (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 184 1.38   533 - 539   557 - 633   640 - 640   647 - 753
2 101 1.62   461 - 532   540 - 556   634 - 639   641 - 646

Sequence


           ___________________________________________________________________________532____539______________556__________________ 
 4k33(A) : ****LPADPKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPG 
         :                                                                                                                          
 6pnx(B) : SELELPADPKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPG 
           ___________________________________________________________________________532____539______________556__________________ 

           ____________________________________________________633__________646____________________________________________________ 
 4k33(A) : LDYSFDTSeQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGI 
         :                                                                                                                          
 6pnx(B) : LD----pEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDEVYTHQSDVWSFGVLLWEIFTLGGSPYPGI 
           ____________________________________________________633__________646____________________________________________________ 

           __________________________________________________________                                                               
 4k33(A) : PVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVT*                                                               
         :                                                                                                                          
 6pnx(B) : PVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTS                                                               
           __________________________________________________________                                                               

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		20.0
Translation
(A) 		-0.1
Closure
(%) 		78.4
Bending Residues
( green ) 		  532 - 533
  539 - 540
  556 - 557
  633 - 634
  636 - 644
  646 - 647
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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