DynDom - Protein Domain Motions

Hexokinase B

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Hexokinase B
Conformer 1 (PDB)	2yhx (A)
Conformer 2 (PDB)	1hkg (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	322	1.0	7 - 60 80 - 85 138 - 139 189 - 192 196 - 430 435 - 440 442 - 456
2	128	1.59	61 - 79 86 - 137 140 - 188 193 - 195 431 - 434 441 - 441

Sequence

`_________________________________________________________60_________________79____85____________________________________` `2yhx(A) : AAAXDXSLVEVHXXVFIVPPXILQAVVSILTTRXDDXDSSAASIPMVPGWVLKQVSGAQAGSFLAIVMGGGDLEVILISLAGRQESSIXASRSLAAAMSTTAIPSDLWGNXAXSNAAFSS` `:` `1hkg(A) : AASXDXSLVEVHXXVFIVPPXILQAVVSIATTRXDDXDSAAASIPMVPGWVLKQVXGSQAGSFLAIVMGGGDLEVILIXLAGYQESSIXASRSLAASMXTTAIPSDLWGNXAXSNAAFSS` `_________________________________________________________60_________________79____85____________________________________` `_____________137________________________________________________188_192_________________________________________________` `2yhx(A) : XEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSLAXLXKLISAMXNAXFPAGDXXXSVADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAYWCDSTXIGDAADGGXXGGAGXMX` `:` `1hkg(A) : XEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSLAXLXKLISAMXNAXFPAGDXXXXVADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAYWCDSTXIADAADAGXXGGAGXMX` `_____________137________________________________________________188_192_________________________________________________` `________________________________________________________________________________________________________________________` `2yhx(A) : ICCDQSSFRKAFPSLPQIXYLXTLNXXSPXAXKTFXKNSXAKNXGQSLRDVLMXFKXXGQXHXXXAXSFXAANVENTSYPAKIQKLPHFDLRXXXDLFXGDQGIAXKTXMKXVVRRXLFL` `:` `1hkg(A) : VCCXQDSFRKAFPSLPQIXYXXTLNXXSPXAXKTFEKNSXAKNXGQSLRDVLMXYKXXGQXHXXXAXDFXAANVENSSYPAKIQKLPHFDLRXXXDLFXGDQGIAXKTXMKXVVRRXLFL` `________________________________________________________________________________________________________________________` `__________________________________________________________________430_434___440__________________` `2yhx(A) : IAAYAFRLVVCXIXAICQKKGYSSGHIAAXGSXRSYSGFSXNSATXNXNIYGWPQSAXXSKPIXITPAIDGXGAASXVIXSIASAXXSXAXXSAXXA` `:` `1hkg(A) : IAAYAFRLVVCXIXAICQKKGYSSGHIAAXGSXRDYSGFSXNSATXNXNIYGWPQSAXXSKPIXITPAIDGEGAAXXVIXSIASSQXXXAXXSAXXA` `__________________________________________________________________430_434___440__________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	13.0
Translation (A)	0.2
Closure (%)	95.6
Bending Residues ( green )	60 - 61 79 - 81 85 - 86 137 - 140 188 - 189 192 - 193 195 - 196 430 - 431 434 - 435 440 - 442
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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