Insulin Receptor

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Insulin Receptor
  Conformer 1
(PDB) 		1p14 (A)
  Conformer 2
(PDB) 		1gag (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 252 1.02   987 - 1004   1010 - 1031   1051 - 1281
2 24 1.61   1005 - 1009   1032 - 1050

Sequence


           _____________________1002___1009_________________1030________________1050_______________________________________________ 
 1p14(A) : VFPSSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAEN 
         :                                                                                                                          
 1gag(A) : ***SSVFVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAEN 
           _____________________1002___1009_________________1030________________1050_______________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1p14(A) : NPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRNLAARNCMVAHDFTVKIGDFG----------------pVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLK 
         :                                                                                                                          
 1gag(A) : NPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIeTDrKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLK 
           ________________________________________________________________________________________________________________________ 

           _______________________________________________________________                                                          
 1p14(A) : FVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENK                                                          
         :                                                                                                                          
 1gag(A) : FVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENK                                                          
           _______________________________________________________________                                                          

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		23.2
Translation
(A) 		-0.8
Closure
(%) 		58.5
Bending Residues
( green ) 		  1002 - 1007
  1009 - 1010
  1030 - 1033
  1050 - 1054
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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