DynDom - Protein Domain Motions

Insulin-Like Growth Factor 1 Receptor

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Insulin-Like Growth Factor 1 Receptor
Conformer 1 (PDB)	7s0q (A)
Conformer 2 (PDB)	7xgd (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	170	5.01	298 - 457 509 - 516 562 - 563
2	292	1.78	3 - 296
3	99	1.72	461 - 508 520 - 558 564 - 575

Sequence

`________________________________________________________________________________________________________________________` `7s0q(A) : EICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLC` `:` `7xgd(B) : EICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLC` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7s0q(A) : YLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTM--kPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYR` `:` `7xgd(B) : YLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYR` `________________________________________________________________________________________________________________________` `__________________________________________________293___________________________________________________________________` `7s0q(A) : FEGWRCVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKI` `:` `7xgd(B) : FEGWRCVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKI` `__________________________________________________293___________________________________________________________________` `______________________________________________________________________________________________457_______________________` `7s0q(A) : RHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWH` `:` `7xgd(B) : RHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWH` `______________________________________________________________________________________________457_______________________` `_________________________508____________________________________________555_____________________________________________` `7s0q(A) : RYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTN*********************` `:` `7xgd(B) : RYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVK` `_________________________508____________________________________________555_____________________________________________` `________________________________________________________________________________________________________________________` `7s0q(A) : ********************************************************************************************************************` `:` `7xgd(B) : WNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKkGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPeYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAE` `________________________________________________________________________________________________________________________` `____________________________________________________________________________________________________________________` `7s0q(A) : ******************************************************************************************************************` `:` `7xgd(B) : KLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAK` `____________________________________________________________________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	78.1
Translation (A)	1.4
Closure (%)	89.9
Bending Residues ( green )	293 - 300
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	71.9
Translation (A)	-0.6
Closure (%)	51.7
Bending Residues ( green )	457 - 461 508 - 520 555 - 564
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification:

No Contacts

PyMOL Script

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