DynDom - Protein Domain Motions

Ketol-Acid Reductoisomerase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Ketol-Acid Reductoisomerase
Conformer 1 (PDB)	3ulk (A)
Conformer 2 (PDB)	1yrl (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	283	0.49	5 - 17 108 - 110 135 - 135 138 - 140 211 - 386 390 - 476
2	198	0.74	18 - 107 111 - 134 136 - 137 141 - 210 387 - 389 477 - 486

Sequence

`_______________17_____________________________________________________________________________________105_______________` `3ulk(A) : MANYFNTLNLRQQLAQLGK-rFMGRDEFADGASYLQGKKVVIVGCGAQGLNQGLNMRDSGLDISYALRKEAIAEKRASWRKATENGFKVGTYEELIPQADLVINLTPDKQHSDVVRTVQP` `:` `1yrl(A) : **NYFNTLNLRQQLAQLGKCRFMGRDEFADGASYLQGKKVVIVGCGAQGLNQGLNMRDSGLDISYALRKEAIAEKRASWRKATENGFKVGTYEELIPQADLVINLTPDKQHSDVVRTVQP` `_______________17_____________________________________________________________________________________105_______________` `___________134___140___________________________________________________________________210______________________________` `3ulk(A) : LMKDGAALGYSHGFNIVEVGEQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKL` `:` `1yrl(A) : LMKDGAALGYSHGFNIVEVGEQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKL` `___________134___140___________________________________________________________________210______________________________` `________________________________________________________________________________________________________________________` `3ulk(A) : VEEGTDPAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKEIMAPLFQKHMDDIISGEFSSGMMADWANDDKKLLTWREETGKTAFETAPQYEGKIGEQEYFDKGVL` `:` `1yrl(A) : VEEGTDPAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKEIMAPLFQKHMDDIISGEFSSGMMADWANDDKKLLTWREETGKTAFETAPQYEGKIGEQEYFDKGVL` `________________________________________________________________________________________________________________________` `______________________385_389__________________________________________________________________________________474______` `3ulk(A) : MIAMVKAGVELAFETMVDSGIIEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFSYACVPLLKPFMAELQPGDLGKAIPEGAVDNGQLRDVNEAIRSHAIEQVGKKLRGY` `:` `1yrl(A) : MIAMVKAGVELAFETMVDSGIIEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFSYACVPLLKPFMAELQPGDLGKAIPEGAVDNGQLRDVNEAIRSHAIEQVGKKLRGY` `______________________385_389__________________________________________________________________________________474______` `_________` `3ulk(A) : MTDMKRIAV` `:` `1yrl(A) : MTDMKRIAV` `_________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	10.6
Translation (A)	-0.4
Closure (%)	55.3
Bending Residues ( green )	17 - 18 105 - 111 134 - 138 140 - 141 210 - 214 385 - 387 389 - 390 474 - 477
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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