Pyruvate Kinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Pyruvate Kinase
  Conformer 1
(PDB) 		1pkl (H)
  Conformer 2
(PDB) 		1a3w (A)
  Window Length 7
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 376 1.84   19 - 90   182 - 492
2 88 1.76   91 - 181

Sequence


           ________________________________________________________________________________________88______________________________ 
 1pkl(H) : SQLAHNLTLSIFDPVANYRAARIICTIGPSTQSVEALKGLIQSGMSVARMNFSHGSHEYHQTTINNVRQAAAEL--GVNIAIALDTKGPEIRTGQFVGG-DAVMERGATCYVTTDPAFAD 
         :                                                                                                                          
 1a3w(A) : ******SRLERLTSLsDLRRTSIIGTIGPKTNNPETLVALRKAGLNIVRMNFSHGSYEYHKSVIDNARKSE-ELYPGRPLAIALDTKGPEIRTGTTTNDVDYPIPPNHEMIFTTDDKYA- 
           ________________________________________________________________________________________89______________________________ 

           ______________________________________________________________181_______________________________________________________ 
 1pkl(H) : KGTKDKF-YIDYQNLSKVVRPGNYIYIDDGILILQVQSHEDEQTLECTVTNSHTISDRRGVNLPGCDVDLPAVSAKDRVDLQFGVEQGVDMIFASFIRSAEQVGDVRKALGPKGRDIMII 
         :                                                                                                                          
 1a3w(A) : KACDDKIMYVDYKNITKVISAGRIIYVDDGVLSFQVLEVVD--tLKVKALNAGKICSHKGVNLPGTDVDLPALSEKDKEDLRFGVKNGVHMVFASFIRTANDVLTIREVLGEQGKDVKII 
           ______________________________________________________________183_______________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1pkl(H) : CKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSA 
         :                                                                                                                          
 1a3w(A) : VKIENQQGVNNFDEILKVTDGVMVARGDLGIEIPAPEVLAVQKKLIAKSNLAGKPVICATQMLESMTYNPRPTRAEVSDVGNAILDGADCVMLSGETAKGNYPINAVTTMAETAVIAEQA 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1pkl(H) : LNEYVFFNSIKKLQHIPMSADEAVCSSAVNSVYETKAKAMVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFFDADKLGH-DEGKEHRVAAGVEFAKSKGYVQTGDY 
         :                                                                                                                          
 1a3w(A) : IAYLPNYDDMRNCTPKPTSTTETVAASAVAAVFEQKAKAIIVLSTSGTTPRLVSKYRPNCPIILVTRCPRAARFSHLYRGVFPFVFEKEPVSDWTDDVEARINFGIEKAKEFGILKKGDT 
           ________________________________________________________________________________________________________________________ 

           ______________________                                                                                                   
 1pkl(H) : CVVIH---ADaNQTRILLVE**                                                                                                   
         :                                                                                                                          
 1a3w(A) : YVSIQGFKAGAGHSNTLQVSTV                                                                                                   
           ______________________                                                                                                   

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		25.7
Translation
(A) 		0.7
Closure
(%) 		24.6
Bending Residues
( green ) 		  88 - 91
  181 - 182
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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