Pyruvate Kinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Pyruvate Kinase
  Conformer 1
(PDB) 		3hqp (I)
  Conformer 2
(PDB) 		2vgb (C)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 390 2.13   7 - 89   177 - 183   188 - 491
2 90 1.36   90 - 176   184 - 187

Sequence


           _________________________________________________________________________________________________________89_____________ 
 3hqp(I) : ***********SQLAHNLTLSI-FDPVANYRAARIICTIGPSTQSVEALKGLIQSGMSVARMNFSHGSHEYHQTTINNVRQAAAELGVN------IAIALDTKGPEIRTGQFVGG---DA 
         :                                                                                                                          
 2vgb(C) : QQQQLPAAMADTFLEHLCLLDIDSEPVAA-RSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEV 
           ________________________________________________________________________________________________________162_____________ 

           __________________________________________________________________________176____183_187________________________________ 
 3hqp(I) : VMERGATCYVTTDPAFADKGTKDKFYIDYQNLSKVVRPGNYIYIDDGILILQVQSHEDEQTLECTVTNSHTISDRRGVNLPGCDVDLPAVSAKDRVDLQFGVEQGVDMIFASFIRSAEQV 
         :                                                                                                                          
 2vgb(C) : ELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEG-LVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDV 
           __________________________________________________________________________251____258_262________________________________ 

           ________________________________________________________________________________________________________________________ 
 3hqp(I) : GDVRKALGPKGRDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYP 
         :                                                                                                                          
 2vgb(C) : AAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFP 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 3hqp(I) : NEVVQYMARICLEAQSALNEYVFFNSIKKLQHIPMSAD--EAVCSSAVNSVYETKAKAMVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFF--DADKLGHDEGKEH 
         :                                                                                                                          
 2vgb(C) : VEAVKMQHAIAREAEAAVYHRQLFEELRRA--APLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADD-VDR 
           ________________________________________________________________________________________________________________________ 

           ___________________________________________                                                                              
 3hqp(I) : RVAAGVEFAKSKGYVQTGDYCVVIHADHKVKGYANQTRILLVE                                                                              
         :                                                                                                                          
 2vgb(C) : RVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSI*                                                                              
           ___________________________________________                                                                              

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		15.8
Translation
(A) 		0.0
Closure
(%) 		89.7
Bending Residues
( green ) 		  89 - 90
  176 - 177
  183 - 184
  187 - 188
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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