Pyruvate Kinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Pyruvate Kinase
  Conformer 1
(PDB)
3hqp (J)
  Conformer 2
(PDB)
2g50 (E)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 389 1.93   19 - 89   179 - 496
2 88 2.02   90 - 178

Sequence


           ___________________________________________________________________________________________________________89___________ 
 3hqp(J) : **************SQLAHNLTLSIFDPVANYRAARIICTIGPSTQSVEALKGLIQSGMSVARMNFSHGSHEYHQTTINNVRQAAAELGVN------IAIALDTKGPEIRTGQFVG-GDA 
         :                                                                                                                          
 2g50(E) : AFIQTQQLHAAMADTFLEHKCRLDIDSAPITARNTGIICTIGPASRSVETLKEMIKSGMNVARMNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTA 
           __________________________________________________________________________________________________________118___________ 

           ______________________________________________________________________________178_______________________________________ 
 3hqp(J) : VME--RGATCYVTTDPAFADKGTKDKFYIDYQNLSKVVRPGNYIYIDDGILILQVQSHEDEQTLECTVTNSHTISDRRGVNLPGCDVDLPAVSAKDRVDLQFGVEQGVDMIFASFIRSAE 
         :                                                                                                                          
 2g50(E) : EVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVDVGSKVYVDDGLISLQVK-QKGPDFLVTEVENGGFLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAA 
           ______________________________________________________________________________209_______________________________________ 

           ________________________________________________________________________________________________________________________ 
 3hqp(J) : QVGDVRKALGPKGRDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGK 
         :                                                                                                                          
 2g50(E) : DVHEVRKILGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMIIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGD 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 3hqp(J) : YPNEVVQYMARICLEAQSALNEYVFFNSIKKLQHIPMSADEAVCSSAVNSVYETKAKAMVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFF-DADKLGHDEGKEHR 
         :                                                                                                                          
 2g50(E) : YPLEAVRMQHLIAREAEAAMFHRKLFEELARASSQSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNHQTARQAHLYRGIFPVVCKDPVQEAWAEDVDLR 
           ________________________________________________________________________________________________________________________ 

           __________________________________________                                                                               
 3hqp(J) : VAAGVEFAKSKGYVQTGDYCVVIHADHKVKGYANQTRILLVE                                                                               
         :                                                                                                                          
 2g50(E) : VNLAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP                                                                               
           __________________________________________                                                                               

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
19.2
Translation
(A)
0.2
Closure
(%)
90.2
Bending Residues
( green )
  89 - 90
  178 - 179
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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