DynDom - Protein Domain Motions

Receptor-Type Tyrosine-Protein Phosphatase Epsilon

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Receptor-Type Tyrosine-Protein Phosphatase Epsilon
Conformer 1 (PDB)	2jjd (D)
Conformer 2 (PDB)	2jjd (E)
Window Length	7
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	279	0.2	115 - 405
2	254	0.28	406 - 688

Sequence

`________________________________________________________________________________________________________________________` `2jjd(D) : *YFPIPVEHLEEEIRIR-kQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLgIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTN` `:` `2jjd(E) : KYFPIPVEHLEEEIRIRcKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLgIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTN` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2jjd(D) : LKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPkAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKV` `:` `2jjd(E) : LKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPkAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKV` `________________________________________________________________________________________________________________________` `________________________________________404_____________________________________________________________________________` `2jjd(D) : DVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSgLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMyTDYINASFIDGYRQKDYFIATQGPLA` `:` `2jjd(E) : DVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSgLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMyTDYINASFIDGYRQKDYFIATQGPLA` `________________________________________404_____________________________________________________________________________` `________________________________________________________________________________________________________________________` `2jjd(D) : HTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNgEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNHPITVHC` `:` `2jjd(E) : HTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNgEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNHPITVHC` `________________________________________________________________________________________________________________________` `_____________________________________________________________` `2jjd(D) : SAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFID` `:` `2jjd(E) : SAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFID` `_____________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	2.6
Translation (A)	0.3
Closure (%)	93.5
Bending Residues ( green )	404 - 406
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Mixed

PyMOL Script

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