Carboxyl-Terminal Src Kinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Carboxyl-Terminal Src Kinase
  Conformer 1
(PDB)
1k9a (F)
  Conformer 2
(PDB)
1k9a (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 219 0.9   8 - 69   78 - 172   179 - 182   184 - 235   250 - 252   262 - 264
2 213 0.83   70 - 77   173 - 178   183 - 183   236 - 249   253 - 261   265 - 448

Sequence


           ______________________________________________________________69______77________________________________________________ 
 1k9a(F) : ASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGK 
         :                                                                                                                          
 1k9a(A) : ASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGK 
           ______________________________________________________________69______77________________________________________________ 

           ____________________________________________172_______182__________________________________________________235__________ 
 1k9a(F) : VEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRH 
         :                                                                                                                          
 1k9a(A) : VEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRH 
           ____________________________________________172_______182__________________________________________________235__________ 

           _249_________261________________________________________________________________________________________________________ 
 1k9a(F) : SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA---pVKWTAPEALREKKFSTKSDVWS 
         :                                                                                                                          
 1k9a(A) : SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASkLPVKWTAPEALREKKFSTKSDVWS 
           _249_________261________________________________________________________________________________________________________ 

           _______________________________________________________________________________                                          
 1k9a(F) : FGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHELHL                                          
         :                                                                                                                          
 1k9a(A) : FGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHELHL                                          
           _______________________________________________________________________________                                          

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
11.7
Translation
(A)
0.5
Closure
(%)
15.2
Bending Residues
( green )
  69 - 70
  77 - 78
  172 - 173
  175 - 179
  182 - 184
  235 - 236
  249 - 250
  252 - 253
  261 - 262
  264 - 265
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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