Insulin Receptor

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Insulin Receptor
  Conformer 1
(PDB)
2b4s (B)
  Conformer 2
(PDB)
2auh (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 227 0.62   1047 - 1066   1068 - 1073   1075 - 1075   1079 - 1281
2 63 1.57   989 - 1046   1067 - 1067   1074 - 1074   1076 - 1078

Sequence


           ___________________________________________________________1046________________1066_1071___1078_________________________ 
 2b4s(B) : ***DEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPP 
         :                                                                                                                          
 2auh(A) : YVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPP 
           ___________________________________________________________1046________________1066_1071___1078_________________________ 

           ________________________________________________________________________________________________________________________ 
 2b4s(B) : PTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIeTDrKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGG 
         :                                                                                                                          
 2auh(A) : PTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIeTDrKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGG 
           ________________________________________________________________________________________________________________________ 

           _________________________________________________________                                                                
 2b4s(B) : YLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENK                                                                
         :                                                                                                                          
 2auh(A) : YLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENK                                                                
           _________________________________________________________                                                                

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
11.3
Translation
(A)
0.3
Closure
(%)
79.6
Bending Residues
( green )
  1046 - 1047
  1066 - 1069
  1071 - 1076
  1078 - 1080
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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