Isocitrate Dehydrogenase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Isocitrate Dehydrogenase
  Conformer 1
(PDB)
1sjs  
  Conformer 2
(PDB)
1hj6 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 210 0.78   5 - 125   134 - 134   325 - 326   329 - 414
2 200 0.57   126 - 133   135 - 324   327 - 328

Sequence


           ________________________________________________________________________________________________________________________ 
 1sjs    : ESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQE 
         :                                                                                                                          
 1hj6(A) : *SKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRELNVALRQE 
           ________________________________________________________________________________________________________________________ 

           _125_____133____________________________________________________________________________________________________________ 
 1sjs    : LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 
         :                                                                                                                          
 1hj6(A) : LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 
           _125_____133____________________________________________________________________________________________________________ 

           ____________________________________________________________________________320_________________________________________ 
 1sjs    : KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAE 
         :                                                                                                                          
 1hj6(A) : KDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAE 
           ____________________________________________________________________________320_________________________________________ 

           _______________________________________________________                                                                  
 1sjs    : MMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM                                                                  
         :                                                                                                                          
 1hj6(A) : MMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM                                                                  
           _______________________________________________________                                                                  

Morph

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Status: Initialising

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
21.4
Translation
(A)
-0.4
Closure
(%)
95.4
Bending Residues
( green )
  125 - 127
  133 - 135
  320 - 329
Bending Region Analysis

Dynamic Contact Graph

The dynamic contact graph is still being generated. Progress: Initialising

PyMOL Script

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