Metabotropic Glutamate Receptor Subtype 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Metabotropic Glutamate Receptor Subtype 1
  Conformer 1
(PDB)
1ewk (B)
  Conformer 2
(PDB)
1ewt (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 284 0.75   37 - 207   235 - 241   343 - 477
2 161 0.62   208 - 234   242 - 342   478 - 510

Sequence


           ________________________________________________________________________________________________________________________ 
 1ewk(B) : QRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIR-------kPIAGVIGPGSSSVAIQVQNLLQ 
         :                                                                                                                          
 1ewt(B) : QRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRkPIAGVIGPGSSSVAIQVQNLLQ 
           ________________________________________________________________________________________________________________________ 

           ____________________________207________________________234____241_______________________________________________________ 
 1ewk(B) : LFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTV 
         :                                                                                                                          
 1ewt(B) : LFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTV 
           ____________________________207________________________234____241_______________________________________________________ 

           ___________________________________________342__________________________________________________________________________ 
 1ewk(B) : RGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINA 
         :                                                                                                                          
 1ewt(B) : RGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINA 
           ___________________________________________342__________________________________________________________________________ 

           ________________________________________________________475_____________________________________                         
 1ewk(B) : IYAMAHGLQNMHHALCPGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKI                         
         :                                                                                                                          
 1ewt(B) : IYAMAHGLQNMHHALCPGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKI                         
           ________________________________________________________475_____________________________________                         

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
8.1
Translation
(A)
-1.2
Closure
(%)
94.3
Bending Residues
( green )
  207 - 208
  234 - 235
  241 - 242
  342 - 346
  475 - 479
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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