Fibroblast Growth Factor Receptor 2

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Fibroblast Growth Factor Receptor 2
  Conformer 1
(PDB) 		2pvf (A)
  Conformer 2
(PDB) 		8e1x (B)
  Window Length 13
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 250 1.36   473 - 643   667 - 759
2 21 5.5   644 - 666

Sequence


           ________________________________________________________________________________________________________________________ 
 2pvf(A) : ELPEDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKP---vTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEs 
         :                                                                                                                          
 8e1x(B) : ELPEDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKd-ATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPL-vIVEYASKGNLREYLRARRPPGMEs 
           ________________________________________________________________________________________________________________________ 

           _______________________________________________640_____________________666______________________________________________ 
 2pvf(A) : Y-----qMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDkKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEEL 
         :                                                                                                                          
 8e1x(B) : YDINReQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINdYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEEL 
           _______________________________________________640_____________________666______________________________________________ 

           _____________________________________________________                                                                    
 2pvf(A) : FKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT                                                                    
         :                                                                                                                          
 8e1x(B) : FKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT                                                                    
           _____________________________________________________                                                                    

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		83.9
Translation
(A) 		0.9
Closure
(%) 		99.6
Bending Residues
( green ) 		  640 - 644
  666 - 671
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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