Hexokinase-1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Hexokinase-1
  Conformer 1
(PDB) 		3b8a (X)
  Conformer 2
(PDB) 		1ig8 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 318 1.34   20 - 74   104 - 106   211 - 211   215 - 458   467 - 480   482 - 482
2 145 1.18   75 - 103   107 - 210   212 - 214   459 - 466   481 - 481   483 - 483

Sequence


           __________________________________________________________74__________________________103_______________________________ 
 3b8a(X) : SMADVPKELMDEIHQLEDMFTVDSETLRKVVKHFIDELNKGLTKKGGNIPMIPGWVMEFPTGKESGNYLAIDLGGTNLRVVLVKLSGNHTFDTTQSKYKLPHDMRTTKHQEELWSFIADS 
         :                                                                                                                          
 1ig8(A) : ***DVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKGGNIPMIPGWVMDFPTGKESGDFLAIDLGGTNLRVVLVKLGGDRTFDTTQSKYRLPDAMRTTQNPDELWEFIADS 
           __________________________________________________________74__________________________103_______________________________ 

           _________________________________________________________________________210_214________________________________________ 
 3b8a(X) : LKDFMVEQELLN-TDTLPLGFTFSYPASQNKINEGILQRWTKGFDIPNVEGHDVVPLLQNEISKRELPIEIVALINDTVGTLIASYYTDPETKMGVIFGTGVNGAFYDVVSDIEKLEGKL 
         :                                                                                                                          
 1ig8(A) : LKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQITKRNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKL 
           _________________________________________________________________________210_214________________________________________ 

           ________________________________________________________________________________________________________________________ 
 3b8a(X) : ADDIPSNSPMAINCEYGSFDNEHLVLPRTKYDVAVDEQSPRPGQQAFEKMTSGYYLGELLRLVLLELNEKGLMLKDQDLSKLKQPYIMDTSYPARIEDDPFENLEDTDDIFQKDFGVKTT 
         :                                                                                                                          
 1ig8(A) : SDDIPPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTT 
           ________________________________________________________________________________________________________________________ 

           __________________________________________________________________________________458_____466___________480_____         
 3b8a(X) : LPERKLIRRLCELIGTRAARLAVCGIAAICQKRGYKTGHIAADGSVYNKYPGFKEAAAKGLRDIYGWTGDASKD-PITIVPAEDGSGAGAAVIAALSEKRIAEGKSLGIIGA         
         :                                                                                                                          
 1ig8(A) : VQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGHIAADGSVYNRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQKRIAEGKSVGIIGA         
           __________________________________________________________________________________459_____467___________481_____         

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		17.1
Translation
(A) 		0.3
Closure
(%) 		96.7
Bending Residues
( green ) 		  74 - 75
  103 - 104
  106 - 107
  210 - 212
  214 - 215
  458 - 459
  466 - 467
  480 - 483
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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