DynDom - Protein Domain Motions

Metabotropic Glutamate Receptor Subtype 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Metabotropic Glutamate Receptor Subtype 1
Conformer 1 (PDB)	3lmk (A)
Conformer 2 (PDB)	6n4y (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	269	0.56	27 - 194 331 - 464
2	165	0.58	195 - 330 465 - 493

Sequence

`________________________________________________________________________________________________________________________` `3lmk(A) : RRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRD-----kPIVGVIGPGSSSVAIQVQNLLQ` `:` `6n4y(A) : ERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISkKPIVGVIGPGSSSVAIQVQNLLQ` `________________________________________________________________________________________________________________________` `____________________________194_________________________________________________________________________________________` `3lmk(A) : LFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGISIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTV` `:` `6n4y(A) : LFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTV` `____________________________194_________________________________________________________________________________________` `____________________________________________330_________________________________________________________________________` `3lmk(A) : RGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEG--------nKTCNSSLTLKTHHVQDSKMGFVINA` `:` `6n4y(A) : RGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINA` `____________________________________________330_________________________________________________________________________` `________________________________________________________462_____________________________________________________________` `3lmk(A) : IYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMD*************************` `:` `6n4y(A) : IYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEiIRSVCSEPCEKkVIRKGEVSCCWT` `________________________________________________________462_____________________________________________________________` `___________________________` `3lmk(A) : *************************` `:` `6n4y(A) : CTPCKENEYVFDEYTCqLGSWPTDDLT` `___________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	29.5
Translation (A)	0.4
Closure (%)	99.9
Bending Residues ( green )	194 - 196 330 - 331 462 - 466
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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