DynDom - Protein Domain Motions

Myosin Va

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Myosin Va
Conformer 1 (PDB)	1w7j (A)
Conformer 2 (PDB)	1oe9 (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	375	2.11	7 - 198 224 - 237 430 - 471 490 - 571 636 - 694
2	231	0.91	199 - 223 238 - 429 574 - 591
3	104	0.97	474 - 483 697 - 790

Sequence

`________________________________________________________________________________________________________________________` `1w7j(A) : AASELYTKYARVWIPDPEEVWKSAELLKDYKPGDKVLQLRLEEGKDLEYCLDPKTKELPPLRNPDILVGENDLTALSYLHEPAVLHNLKVRFIDSKLIYTYCGIVLVAINPYEQLPIYGE` `:` `1oe9(A) : *ELYTKYARVWIPDPEEVWKSAELLKDYKPGDKVLQLRL----dLEYCL----kELPPLRNPDILVGENDLTALSYLHEPAVLHNLKVRFIDSKLIYTYCGIVLVAINPYEQLPIYGE` `________________________________________________________________________________________________________________________` `___________________________________________________________183_____________________________________223___________237____` `1w7j(A) : DIINAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGSASEANVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRT` `:` `1oe9(A) : DIINAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVS------nVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRT` `___________________________________________________________183_____________________________________223___________237____` `________________________________________________________________________________________________________________________` `1w7j(A) : YLLEKSRVVFQAEEERNYHIFYQLCASAALPEFKTLRLGNANYFHYTKQGGSPVIDGIDDAKEMVNTRQACTLLGISDSYQMGIFRILAGILHLGNVEFASRDSDSCAIPPKHDPLTIFC` `:` `1oe9(A) : YLLEKSRVVFQAEEERNYHIFYQLCASAALPEFKTLRLGNANYFHYTKQGGSPVIDGIDDAKEMVNTRQACTLLGISDSYQMGIFRILAGILHLGNVEFASRDSDSCAIPPKHDPLTIFC` `________________________________________________________________________________________________________________________` `_______________________________________________________________427_________________________________________471_________4` `1w7j(A) : DLMGVDYEEMAHWLCHRKLATATETYIKPISKLHAINARDALAKHIYANLFNWIVDHVNKALHSTVKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQ` `:` `1oe9(A) : DLMGVDYEEMAHWLCHRKLAt----YIKPISKLHAINARDALAKHIYANLFNWIVDHVNKALHSTVKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQ` `_______________________________________________________________427_________________________________________471_________4` `83__________________________________________________________________________________568____________________591__________` `1w7j(A) : IPWTLIDFYDNQPCINLIEAKMGVLDLLDEECKMPKGSDDTWAQKLYNTHLNKCALFEKPRLSNKAFIIKHFADKVEYQCEGFLEKNKDTVYEEQIKVLKSSKKFKLLPELF-QkTVGHQ` `:` `1oe9(A) : IP----dFYDNQPCINLIEAKMGVLDLLDEECKMPKGSDDTWAQKLYNTHLNKCALFEKPRLSNKAFIIKHFADKVEYQCEGFLEKNKDTVYEEQIKVLKSSKKFKLLPELFhKKTVGHQ` `83__________________________________________________________________________________568____________________591__________` `____________________________________________________694_________________________________________________________________` `1w7j(A) : FRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVLSDRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAYL` `:` `1oe9(A) : FRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVLSDRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAYL` `____________________________________________________694_________________________________________________________________` `___________________________________` `1w7j(A) : EKIRADKLRAACIRIQKTIRGWLMRKKYMRMRR` `:` `1oe9(A) : EKIRADKLRAACIRIQKTIRGWLMRKKYMRMRRGD` `___________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	18.9
Translation (A)	0.3
Closure (%)	12.4
Bending Residues ( green )	183 - 199 223 - 224 237 - 238 427 - 430 568 - 574 591 - 636
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	24.5
Translation (A)	-2.0
Closure (%)	76.9
Bending Residues ( green )	471 - 475 483 - 490 694 - 698
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

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