DynDom - Protein Domain Motions

P2x Purinoceptor 7

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	P2x Purinoceptor 7
Conformer 1 (PDB)	6u9v (A)
Conformer 2 (PDB)	6u9w (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	478	2.39	7 - 111 172 - 293 309 - 593
2	75	1.45	112 - 171 294 - 308

Sequence

`_________________________________________________________________________________________________________111____________` `6u9v(A) : CCSWNDVFQYETNKVTRIQSVNYGTIKWILHMTVFSYVSFALMSDKLYQRKEPLISSVHTKVKGVAEVTENVt-----KLVHGIFDTADYTLPLQGNSFFVMTNYLKSEGQEQKLCPEYP` `:` `6u9w(A) : *CSWNDVFQYETNKVTRIQSVNYGTIKWILHMTVFSYVSFALMSDKLYQRKEPLISSVHTKVKGVAEVTENVTEGGVTKLVHGIFDTADYTLPLQGNSFFVMTNYLKSEGQEQKLCPEYP` `_________________________________________________________________________________________________________111____________` `_____________________________________________171________________________________________________________________________` `6u9v(A) : SRGKQCHSDQGCIKGWMDPQSKGIQTGRCIPYDQKRKTCEIFAWCPAEEGKEAPRPALLRSAENFTVLIKNNIDFPGHNYTTRNILPGMNISCTFHKTWNPQCPIFRLGDIFQEIGENFT` `:` `6u9w(A) : SRGKQCHSDQGCIKGWMDPQSKGIQTGRCIPYDQKRKTCEIFAWCPAEEGKEAPRPALLRSAENFTVLIKNNIDFPGHNYTTRNILPGMNISCTFHKTWNPQCPIFRLGDIFQEIGENFT` `_____________________________________________171________________________________________________________________________` `_______________________________________________293____________308_______________________________________________________` `6u9v(A) : EVAVQGGIMGIEIYWDCNLDSWSHRCQPKYSFRRLDDKYTNESLFPGYNFRYAKYYKENGMEKRTLIKAFGVRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLIINTYASTCC` `:` `6u9w(A) : EVAVQGGIMGIEIYWDCNLDSWSHRCQPKYSFRRLDDKYTNESLFPGYNFRYAKYYKENGMEKRTLIKAFGVRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLIINTYASTCC` `_______________________________________________293____________308_______________________________________________________` `________________________________________________________________________________________________________________________` `6u9v(A) : RSRVYPSCKCCEPCAVNEYYYRKKCEPIVEPKPTLKYVSFVDEPHIWMVDQQLLGKSLQDVKGQEVPRPQTDFLELSRLsRDSPDWCQCGNCLPSQLPENRRALEELCCRRKPGQCITTS` `:` `6u9w(A) : RSRVYPSCKCCEPCAVNEYYYRKKCEPIVEPKPTLKYVSFVDEPHIWMVDQQLLGKSLQDVKGQEVPRPQTDFLELSRL--dSPDWCQCGNCLPSQLPENRRALEELCCRRKPGQCITTS` `________________________________________________________________________________________________________________________` `_____________________________________________________________________________________` `6u9v(A) : ELFSKIVLSREALQLLLLYQEPLLALEGEAINSKLRHCAYRSYATWRFVSQDMADFAILPSCCRWKIRKEFPKTQGQYSGFKYPY` `:` `6u9w(A) : ELFSKIVLSREALQLLLLYQEPLLALEGEAINSKLRHCAYRSYATWRFVSQDMADFAILPSCCRWKIRKEFPKTQGQYSGFKYPY` `_____________________________________________________________________________________`

Morph

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Status: Initialising

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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	15.9
Translation (A)	-1.1
Closure (%)	41.4
Bending Residues ( green )	111 - 112 171 - 172 293 - 294 308 - 309
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

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