Pyruvate Kinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Pyruvate Kinase
  Conformer 1
(PDB) 		1e0t (A)
  Conformer 2
(PDB) 		1pky (B)
  Window Length 7
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 343 0.47   4 - 70   164 - 164   169 - 467
2 97 0.34   71 - 163   165 - 168

Sequence


           ____________________________________________________________________70__________________________________________________ 
 1e0t(A) : MKKTKIVCTIGPKTESEEMLAKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKTAAILLDTKGPEIRTMKLEGGNDVSLKAGQTFTFTTDKSVIGNSEMVAVTYEGFTTDLSVG 
         :                                                                                                                          
 1pky(B) : MKKTKIVCTIGPKTESEEMLAKMLDAGMNVMRLNFSHGDYAEHGQRIQNLRNVMSKTGKTAAILLDTKGPEIRTMKLEGGNDVSLKAGQTFTFTTDKSVIGNSEMVAVTYEGFTTDLSVG 
           ____________________________________________________________________70__________________________________________________ 

           ________________________________________163__168________________________________________________________________________ 
 1e0t(A) : NTVLVDDGLIGMEVTAIEGNKVICKVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVIEIREHLKAHGGENIHIISKIENQEGLNNFDEILEASDGI 
         :                                                                                                                          
 1pky(B) : NTVLVDDGLIGMEVTAIEGNKVICKVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVIEIREHLKAHGGENIHIISKIENQEGLNNFDEILEASDGI 
           ________________________________________163__168________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1e0t(A) : MVARGDLGVEIPVEEVIFAQKMMIEKCIRARKVVITATM---------rPTDAEAGDVANAILDGTDAVMLSGE------pLEAVSIMATICERTDRVMNSRLE---iTEAVCRGAVETA 
         :                                                                                                                          
 1pky(B) : MVARGDLGVEIPVEEVIFAQKMMIEKCIRARKVVITATMMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRVMNSRLEkLRITEAVCRGAVETA 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________                 
 1e0t(A) : EKLDAPLIVVATQGGKSARAVRKYFPDATILALTTNEKTAHQLVLSKGVVPQLVKEITSTDDFYRLGKELALQSGLAHKGDVVVMVSGALVPSGTTNTASVHVL                 
         :                                                                                                                          
 1pky(B) : EKLDAPLIVVATQGGKSARAVRKYFPDATILALTTNEKTAHQLVLSKGVVPQLVKEITSTDDFYRLGKELALQSGLAHKGDVVVMVSGALVPSGTTNTASVHVL                 
           ________________________________________________________________________________________________________                 

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		3.7
Translation
(A) 		-0.5
Closure
(%) 		37.6
Bending Residues
( green ) 		  70 - 71
  163 - 165
  168 - 169
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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