DynDom - Protein Domain Motions

Receptor-Type Tyrosine-Protein Phosphatase Epsilon

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Receptor-Type Tyrosine-Protein Phosphatase Epsilon
Conformer 1 (PDB)	2jjd (E)
Conformer 2 (PDB)	2jjd (F)
Window Length	13
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	291	0.13	117 - 430 657 - 660 662 - 663
2	237	0.27	431 - 656 661 - 661 664 - 685

Sequence

`________________________________________________________________________________________________________________________` `2jjd(E) : KYFPIPVEHLEEEIRIR--cKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLgIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVML` `:` `2jjd(F) : KYFPIPVEHLEEEIRIRSAcKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLgIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVML` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2jjd(E) : TNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPkAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQ` `:` `2jjd(F) : TNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPkAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQ` `________________________________________________________________________________________________________________________` `________________________________________________428_____________________________________________________________________` `2jjd(E) : KVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSgLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMyTDYINASFIDGYRQKDYFIATQGP` `:` `2jjd(F) : KVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSgLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSM-tDYINASFIDGYRQKDYFIATQGP` `________________________________________________428_____________________________________________________________________` `________________________________________________________________________________________________________________________` `2jjd(E) : LAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNgEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNHPITV` `:` `2jjd(F) : LAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNgEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNHPITV` `________________________________________________________________________________________________________________________` `_________________________656___________________________________` `2jjd(E) : HCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFID` `:` `2jjd(F) : HCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFID` `_________________________656___________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	1.6
Translation (A)	0.2
Closure (%)	71.2
Bending Residues ( green )	428 - 440 656 - 664
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

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